Home | Cellular Molecular Medicine

Time 2020-06-26 07:04:50

Web Name: Home | Cellular Molecular Medicine

WebSite: http://cmm.arizona.edu

ID:11074

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Curtis Thorne, PhDDiscovering Signals Controlling Cell Fate of Regenerative TissuesDarren Cusanovich, PhDUnderstanding How the Genome Regulates Diverse Cell Types in Development and DiseaseGus Mouneimne, PhDUnderstanding How Cytoskeletal Architecture Regulates Cancer MetastasisDonata Vercelli, MDUncovering mechanisms that control susceptibility to complex lung diseasesNoel Warfel, PhDModeling the Effects of Hypoxia on Cancer Cells and Tumor AngiogenesisBrett Colson, PhDDeciphering the Structural Basis for Muscle Contraction at the Molecular LevelJared Churko, PhDInformatics to Understand Cardiovascular Development and Disease Mechanisms Message from the Chair The mission of the Department of Cellular and Molecular Medicine (CMM) is to provide pre- and post-doctoral, medical and graduate education in an interdisciplinary environment through research activities, to advance knowledge of biological structure as related to function and disease from the molecular level to the whole organism. Read More Systems Genetics in Human Endothelial Cells Identifies Non-coding Variants Modifying Enhancers, Expression, and Complex Disease Traits. Author(s): L.K. Stolze; A.C. Conklin; M.B. Whalen; M.López Rodríguez; K. Õunap; I. Selvarajan; A. Toropainen; T. Örd; J. Li; A. Eshghi; A.E. Solomon; Y. Fang; M.U. Kaikkonen; C.E. Romanoski Date Published: 2020 May 16 PMID: 32442411 Study of the Expression Transition of Cardiac Myosin Using Polarization-Dependent SHG Microscopy. Author(s): C. Yuan; X. Zhao; Z. Wang; T.K. Borg; T. Ye; Z.I. Khalpey; R.B. Runyan; Y. Shao; B.Z. Gao Date Published: 2020 Mar 10 PMCID: PMC7063480 PMID: 31995740 HNF4a transcription is a target of trichloroethylene toxicity in the embryonic mouse heart. Author(s): S. Chen; A. Lencinas; M. Nunez; O.I. Selmin; R.B. Runyan Date Published: 2020 Mar 01 PMCID: PMC7250168 PMID: 32159184 Triggering typical nemaline myopathy with compound heterozygous nebulin mutations reveals myofilament structural changes as pathomechanism. Author(s): J. Lindqvist; W. Ma; F. Li; Y. Hernandez; J. Kolb; B. Kiss; P. Tonino; R. van der Pijl; E. Karimi; H. Gong; J. Strom; Z. Hourani; J.E. Smith; C. Ottenheijm; T. Irving; H. Granzier Date Published: 2020 Jun 01 PMID: 32483185 Guidelines and definitions for research on epithelial-mesenchymal transition. Author(s): J. Yang; P. Antin; G. Berx; C. Blanpain; T. Brabletz; M. Bronner; K. Campbell; A. Cano; J. Casanova; G. Christofori; S. Dedhar; R. Derynck; H.L. Ford; J. Fuxe; A.García de Herreros; G.J. Goodall; A.K. Hadjantonakis; R. J Y Huang; C. Kalcheim; R. Kalluri; Y. Kang; Y. Khew-Goodall; H. Levine; J. Liu; G.D. Longmore; S.A. Mani; J. Massagué; R. Mayor; D. McClay; K.E. Mostov; D.F. Newgreen; A. Nieto; A. Puisieux; R. Runyan; P. Savagner; B. Stanger; M.P. Stemmler; Y. Takahashi; M. Takeichi; E. Theveneau; J.Paul Thiery; E.W. Thompson; R.A. Weinberg; E.D. Williams; J. Xing; B.P. Zhou; G. Sheng Date Published: 2020 Jun PMID: 32300252 Romanoski Lab links DNA polymorphisms to individual disease risk in AJHG (June 4, 2020) Research from Casey Romanoski, PhD's Laboratory - led by Genetics PhD student Lindsey Stolze - linked polymorphisms in people's DNA sequence with molecular characteristics of how cells convert genetic code into the building blocks for proteins. This report is among the very first to use molecular Quantiative Trait Locus mapping at such depth, and the first to apply it in human endothelial cells. The authors pinpoint DNA polymorphisms that cause particular genes to be made into cellular building blocks at different rates across people, which serves as a springboard for understanding individualized disease risk and mechanisms to overcome it.  PMID: 32442411 Granzier Lab describes new model of nemaline myopathy in Nature Communications (June 3, 2020) Johan Lindqvist, PhD and the laboratory of Henk Granzier, PhD recently published a paper in Nature Communications describing a novel mouse model of nemaline myopathy, a heterogenous disease with unclear pathological mechanisms. This novel mouse model mimics the most common genetic cause of the nemaline myopathy and demonstrates that the muscle weakness in this model is associated with twisted actin filaments and altered tropomyosin and troponin behavior. PMID: 32483185 Dr. Helen Amerongen receives 2020 Faculty Mentoring Award (May 21, 2020) Helen Amerongen, PhD was recently awarded a 2020 College of Medicine Mentoring Award, which honors faculty members who demonstrate outstanding commitment to the mentorship of junior faculty.  Recipients were formally recognized at the May General Faculty Meeting of the College of Medicine – Tucson.  Read more here Dr. Darren Cusanovich selected for a University of Arizona Health Sciences Career Development Award (April 30, 2020) Research Assistant Professor Darren Cusanovich, PhD was announced as one of four recipients of the UAHS Career Development Award this year. The CDA program, established in 2014, provides research training and funding for junior faculty members to foster academic careers in clinical and translational research. The award will support Dr. Cusanovich's work, in collaboration with Dr. Mohamed Ahmed in Neonatology, using single-cell genomics to better understand the pathogenesis of bronchopulmonary dysplasia, a lung disease that affects prematurely born children. Read more here. Dr. Gregory Rogers receives $2.6M Maximizing Investigators’ Research Award (MIRA) R35 from the NIGMS (April 29, 2020) Associate Professor Gregory Rogers, PhD, recently received an R35 MIRA grant, a 5-year award for established investigators from the NIGMS.  The goal of this basic science proposal is to utilize Drosophila melanogaster as a model system to dissect the molecular mechanisms that underlie the assembly, growth, and function of centrioles - the core subunits of centrosomes. Dr. Thorne s laboratory receives COVID-19 Rapid Turn-Around Seed Grant (April 16, 2020) Assistant Professor Curtis Thorne, PhD in collaboration with Dr. Koenraad Van Doorslaer were awarded a Technology and Research Initiative Fund (TRIF) grant from the BIO5 Institute. The goal of their project is to rapidly test bioactive, clinically actionable and structurally diverse compounds for their activity in disrupting COVID-19 replication in bronchial tissue models. To accomplish this, Thorne and Van Doorslaer are developing a novel high-throughput assay to tract viral replication at the sub-cellular level with plans to make all data available in realtime to the international scientific community. Drs. Curtis Thorne (left) and Koenraad Van Doorslaer (right) were featured on Tucson News KOLD-TV to discuss their high-throughput assay that tracks the effect of FDA approved drugs on novel coronavirus replication in lung cells. UA College of Medicine Department of Cellular Molecular Medicine 1501 N. Campbell Avenue PO Box 245044 Tucson Arizona 85724-5044 Tel: (520) 626-6084 | Fax: (520) 626-2097 | Admin

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