Millar Lab
Time 2020-12-23 04:03:26Web Name: Millar Lab
WebSite: http://millar.bio.ed.ac.uk
ID:143233
Keywords:
Millar,Lab,Description:
!! This is the archived website of Professor Andrew J. Millar's research group at the University of Edinburgh (to 2017) !! Current work is linked from here: http://www.amillar.org Plants, fungi, animals, some bacteria and archaea have internal, 24-hour clocks. These circadian clocks affect our lives in many ways, through industry, agriculture and human health. Web tutorials on biological clocks: try these old pages first, if circadian clocks are new to you. Our research aims to understand how the circadian clock is constructed and adjusted, how it affects plant life and why the clock mechanisms are so complex. Among the cogs of the biological clockwork are a small set of genes that rhythmically regulate each other's activity. We study these clock genes in Arabidopsis, which is a small plant with a big following, and the marine alga Ostreococcus, which is one of the smallest eukaryotic cells. Molecular genetics and transgenic plants/algae help us by revealing rhythms that are usually invisible: we use a reporter gene called luciferase to send us video footage when other genes are active, like the 24-hour loop at the top of this page. We are also studying how biological rhythms benefit the organism by controlling metabolism, growth and seasonal flowering times, using quantitative timeseries experiments and mathematical modelling. The circadian clock is an excellent system to develop new methods in Systems Biology, as we do with many collaborators in SynthSys. Mathematical modelling helps us to understand the complex data and to identify the principles behind the molecular detail. We were using the simpler clock of Ostreococcus to test those principles, when we also discovered a different, non-transcriptional clock mechanism that does not require rhythmic gene activity. We are now using proteomics and chemical biology to identify the cogs and gears of this ancient clock. PhD studentship projects.<<< Thank you for your visit >>>
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