Home Page: Experimental Hematology

Time 2020-12-21 23:06:52

Web Name: Home Page: Experimental Hematology

WebSite: http://www.exphem.org

ID:141994

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Page,Home,Hematology,

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Arid2 regulates HSC differentiation in normal hematopoiesisTheresa Bluemn, Jesse Schmitz, Yuhong Chen, Yongwei Zheng, Yongguang Zhang, Shikan Zheng, Robert Burns, Joshua DeJong, Luke Christiansen, Jesus Izaguirre-Carbonell, Demin Wang, Nan ZhuDOI: https://doi.org/10.1016/j.exphem.2020.12.004Publication stage: In Press Journal Pre-ProofOpen AccessPreviewFull-Text HTMLPDFSupplemental MaterialsxAdult hematopoiesis originates from the hematopoietic stem cells (HSCs) which reside in the bone marrow. HSCs are multipotent, adult stem cells with the hallmark ability to self-renew and differentiate into all blood lineages. Epigenetic regulators have been shown to play important roles in HSC function and their dysregulation leads to hematological malignancies [1]. These includes the Switch/Sugar Non-Fermenting (SWI/SNF) family of chromatin remodeling complexes [2–4].Persistent expression of microRNA-125a is required to induce murine hematopoietic stem cell repopulating activityDG Luinenburg, AB Dinitzen, A Flohr Svendsen, R Cengiz, A Ausema, E Weersing, L Bystrykh, G de HaanDOI: https://doi.org/10.1016/j.exphem.2020.12.002Publication stage: In Press Journal Pre-ProofOpen AccessPreviewFull-Text HTMLPDFSupplemental MaterialsxHematopoietic stem cells (HSCs) are responsible for the lifelong reconstitution of all mature blood cells. As differentiation of these cells is non-reversible and terminal, the balance between self-renewal and differentiation of HSCs is tightly regulated to ensure proper tissue function. Proper HSC function is regulated both extrinsically by environmental factors that are secreted by the supporting cells in the bone marrow known as the stem cell niche, and by stem cell intrinsic programs. One of these cell-intrinsic regulatory components that control HSC function are microRNAs (miRs).How hematopoietic stem cells respond to irradiation: similarities and differences between low versus high doses of ionizing radiationElia Henry, Marie-Laure ArcangeliDOI: https://doi.org/10.1016/j.exphem.2020.12.001Publication stage: In Press Journal Pre-ProofPreviewFull-Text HTMLPDFxScientific understanding of radiation effects is a constantly evolving field. However, it can be sometimes tricky to define doses of radiation, given the different units in which it can be expressed. The “absorbed dose” is expressed in Gray (Gy) while the “equivalent dose” and the “efficient dose” are expressed in Sievert (Sv). While they both correspond to the same units in the International Units System (J/kg), the relationship between these parameters implies several multiplicative factors taking into account the type of radiation, the organ sensitivity or the species [1].Engineering human hematopoietic environments through ossicle and bioreactor technologies exploitationPia Sommerkamp, François E. Mercier, Adam C. Wilkinson, Dominique Bonnet, Paul E. BourgineDOI: https://doi.org/10.1016/j.exphem.2020.11.008Publication stage: In Press Corrected ProofPreviewFull-Text HTMLPDFxHematopoietic stem and progenitor cells (HSPCs), residing primarily within the bone marrow (BM), sustain lifelong hematopoiesis [1–4]. The BM microenvironment is composed of a range of cell types—from mesenchymal stromal cells (MSCs) and endothelium to various mature hematopoietic cell types—and provide various supportive extrinsic cues [5,6]. The accumulation of somatic mutations within HSPCs is well described as driver of a range of hematological disorders such as myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPNs), and leukemias [7–12].Salvianolic acid A inhibits the growth of diffuse large B-cell lymphoma through MAPK pathwaysShuting Li, Jingwen Fang, Ting Si, Ying Lu, Lei JiangDOI: https://doi.org/10.1016/j.exphem.2020.11.007Publication stage: In Press Corrected ProofPreviewFull-Text HTMLPDFxDiffuse large B-cell lymphoma (DLBCL), an immense heterogeneous disease, can be categorized into two major molecular subtypes: germinal center B-cell-like (GCB) and activated B-cell-like (ABC) DLBCL [1]. This molecular distinction represents lymphomas deriving from different stages of B-cell differentiation and reflects fairly different intracellular oncogenic pathways for pathogenesis [2–4]. Although the combinatorial chemotherapy R-CHOP (rituximab with cyclophosphamide, doxorubicin, vincristine, and prednisone) makes the majority of patients curable [5], a subset exhibits severe side effects or relapses after initial treatment. How to get a Fast Track Submission? Experimental Hematology also offers a Fast Track Submission. Expedited review will be offered, on request, for research articles that have been previously considered by other top ranked journals.Watch the prezi presentation for further details. About Experimental Hematology Experimental Hematology publishes original research reports (regular and fast-track submissions), reviews, letters to the editor, and abstracts of the annual meeting of ISEH - International Society for Experimental Hematology. We welcome manuscripts describing basic in vitro and in vivo research centered on normal and malignant hematopoiesis as well as non-malignant hematologic diseases. Submissions focused on non-hematopoietic stem cells (e.g. mesenchymal stem cells, embryonic stem cells and induced pluripotent stems) with potential relevance to hematopoiesis are also welcome, as are studies involving experimental or early phase clinical cell transplantation. Studies employing genomic and systems biology approaches to the study of normal and malignant hematopoiesis are strongly encouraged, as are those employing model organisms. ISEH Member Access For seamless access to Experimental Hematology content, ISEH members should first log into the ISEH website, then click on "Experimental Hematology ." Green Open Access/Self Archiving Elsevier supports various forms of Green Open Access and author posting of manuscripts – please see here for details

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