Cell Therapy News Science News

Time 2020-12-21 23:06:51

Web Name: Cell Therapy News Science News

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Category Archives: Cell Therapy Cell Therapy NewsCell Therapy News is an online publication and email newsletter dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.SubscribePublished weekly since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations. Screening of chimeric antigen receptor (CAR) T cells identified dependencies for effector functions, including TLE4 and IKZF2. Targeted knockout of these genes enhanced CAR anti-tumor efficacy. Cancer Discovery Wang, D., Prager, B. C., Gimple, R. C., Aguilar, B., Alizadeh, D., Tang, H., Lv, D., Starr, R., Brito, A., Wu, Q., Kim, L. J. Y., Qiu, Z., Lin, P., Lorenzini, M. H., Badie, B., Forman, S. J., Xie, Q., Brown, C. E., Rich, J. N. (2020). CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies. Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-20-1243 Cite Scientists provide an overview of clinical results obtained through the use of haploidentical transplantation in severe aplastic anemia, mainly focusing on current advances and future challenges. Bone Marrow Transplantation Xu, Z.-L., Huang, X.-J. (2020). Haploidentical stem cell transplantation for aplastic anemia: the current advances and future challenges. Bone Marrow Transplantation, 1 7. https://doi.org/10.1038/s41409-020-01169-7 Cite Scientists showed that transplant sarcomas are cured by PD-1 blockade and radiotherapy, but identical treatment failed in autochthonous sarcomas, which demonstrated immunoediting, decreased neoantigen expression, and tumor-specific immune tolerance. Nature Communications Wisdom, A. J., Mowery, Y. M., Hong, C. S., Himes, J. E., Nabet, B. Y., Qin, X., Zhang, D., Chen, L., Fradin, H., Patel, R., Bassil, A. M., Muise, E. S., King, D. A., Xu, E. S., Carpenter, D. J., Kent, C. L., Smythe, K. S., Williams, N. T., Luo, L., Kirsch, D. G. (2020). Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy. Nature Communications, 11(1), 6410. https://doi.org/10.1038/s41467-020-19917-0 Cite investigators generated B7-H3- CAR T cells and evaluated their antitumor activity in vitro and in vivo. Neuro-Oncology Haydar, D., Houke, H., Chiang, J., Yi, Z., Od , Z., Caldwell, K., Zhu, X., Mercer, K. S., Stripay, J. L., Shaw, T. I., Vogel, P., DeRenzo, C., Baker, S. J., Roussel, M. F., Gottschalk, S., Krenciute, G. (2020). Cell surface antigen profiling of pediatric brain tumors: B7-H3 is consistently expressed and can be targeted via local or systemic CAR T-cell delivery. Neuro-Oncology, noaa278. https://doi.org/10.1093/neuonc/noaa278 Cite Researchers present a ligand-controlled chimeric antigen receptor (CAR) system, based on the IKZF3 ZF2 β-hairpin IMiD-inducible degron, which allows for the reversible control of expression levels of type I membrane proteins, including CARs. Cell Chemical Biology Carbonneau, S., Sharma, S., Peng, L., Rajan, V., Hainzl, D., Henault, M., Yang, C., Hale, J., Shulok, J., Tallarico, J., Porter, J., Brogdon, J., Dranoff, G., Bradner, J. E., Hild, M., Guimaraes, C. P. (2020). An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity. Cell Chemical Biology, 0(0). https://doi.org/10.1016/j.chembiol.2020.11.012 Cite CRISPR Therapeutics AG announced the receipt of a grant from the Bill Melinda Gates Foundation to research in vivo gene editing therapies for the treatment of HIV. CRISPR Therapeutics AG Scientists examine the efficacy of a human bone marrow-derived MSC therapy delivered at three or 30 hours in ameliorating radiation-induced hematopoietic syndrome and show that pancytopenia persists despite MSC therapy. Scientific Reports Diaz, M. F., Horton, P. lina D., Dumbali, S. P., Kumar, A., Livingston, M., Skibber, M. A., Mohammadalipour, A., Gill, B. S., Zhang, S., Cox, C. S., Wenzel, P. L. (2020). Bone marrow stromal cell therapy improves survival after radiation injury but does not restore endogenous hematopoiesis. Scientific Reports, 10(1), 22211. https://doi.org/10.1038/s41598-020-79278-y Cite Monash University congratulates the School of Clinical Sciences student Amber Wang the highest achieving student in the 2020 BMedSc(Hons) cohort. Wang s research title was Effect of Umbilical Cord Blood Cell Therapy on Grey Matter Vascular Injury in the Growth-Restricted Fetal Brain . Monash University Investigators discuss and evaluate research surrounding these key assumptions and the clinical success of in utero stem cell transplantationin the treatment of thalassemia. Stem Cells and Development Tai-macarthur, S., Lombardi, G., Shangaris, P. (2020). The Theoretical Basis of In Utero Hematopoietic Stem Cell Transplantation and its use in the treatment of Blood disorders. Stem Cells and Development. https://doi.org/10.1089/scd.2020.0181 Cite Overall HLA class I mismatch was also a significant risk factor and the predictor of post-cord blood transplantation viral infection, probably due to the insufficient cytotoxic T cell recognition and dendritic cell priming. Scientific Reports Iemura, T., Arai, Y., Kanda, J., Kitawaki, T., Hishizawa, M., Kondo, T., Yamashita, K., Takaori-Kondo, A. (2020). Impact of HLA class I allele-level mismatch on viral infection within 100 days after cord blood transplantation. Scientific Reports, 10(1), 21150. https://doi.org/10.1038/s41598-020-78259-5 Cite Graphite Bio announced that the FDA has cleared its investigational new drug application (IND) for the experimental gene editing therapy GPH101 to initiate a Phase I/II clinical trial in patients with severe sickle cell disease. Graphite Bio Sort by DateSort by Impact Factor ResetVideo-ad-box

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