TwinStrand Biosciences - An end-to-end solution, from pre-sequencing biochemistry to post-sequencing

Web Name: TwinStrand Biosciences - An end-to-end solution, from pre-sequencing biochemistry to post-sequencing






Technology Applications AML MRD Mutagenesis Cellular Immunotherapy Collaborate Resources Publications Posters Safety Patents Company Our Team Careers Events News Investors Contact Technology Applications AML MRD Mutagenesis Cellular Immunotherapy Collaborate Resources Publications Posters Safety Patents Company Our Team Careers Events News Investors Contact Chimerism detection at one-in-one-million sensitivity Learn More

Mutation frequency, spectra, and signatures directly from DNA
Learn More

Identify AML-related mutations with 100-fold higher resolution Learn More

Highest Resolution Next-Generation Sequencing (NGS)

TwinStrand Duplex Sequencing™ technology reduces your sequencing error rates from 1-in-100 to 1-in-10 million, revealing data otherwise hidden. Using a combination of proprietary biochemistry and cloud-based informatics, the limitations of standard sequencing are overcome by independently tracking both strands of individual DNA molecules and comparing the results to eliminate errors.


Detect Rare Variants Like Never Before

Whether you are studying measurable residual disease, mutation signatures, cellular immunotherapy monitoring, or any low-level variants, you need accuracy beyond standard NGS. TwinStrand Duplex Sequencing reveals important low frequency variants that aren’t detectable by other methods. Get started with an off-the-shelf kit, or collaborate with us on a custom kit for your specific needs.


In The Spotlight

This year we were proud to sponsor the scientific workshop Applying Molecular Biology & Genetic Toxicology Methods to Improve Risk Assessment and Guide Risk Management Decisions for Cancer in Firefighters at the 2022 National Cancer Fire Symposium, hosted by the Firefighter Cancer Initiative (FCI). View this talk by our CEO Jesse Salk from the event.



Singular Genomics and TwinStrand Biosciences Collaborate to Develop Ultra-high Accuracy NGS Solutions for the G4 Platform



Cancer Genomics Consortium (CGC) 13th Annual Meeting 2022 – July 31 – August 3, 2022



Direct Quantification of In Vivo Mutagenesis and Carcinogenesis Using Duplex Sequencing


Customer Quotes

“Mutagenicity testing is a requirement for all pharmaceuticals and chemicals used in commerce. The conventional tests used today to identify whether chemicals and drugs cause mutations are decades old and generally investigate a single gene at a time in select organisms. We believe that TwinStrand Duplex Sequencing can revolutionize mutagenicity testing by enabling the precise quantification and characterization of mutations in any gene in any organism. Our initial work, in partnership with Dr. Francesco Marchetti at Health Canada, is establishing experimental designs and analytical approaches for mutagenicity testing in human cells and rodent models.”

Carole Yauk
Professor, University of Ottawa
President of the Environmental Mutagenesis and Genomics Society

“My lab’s interactions with TwinStrand have been as much a scientific collaboration as a business relationship. We have worked closely with TwinStrand researchers to develop new panels for mutation detection, and to best leverage Duplex Sequencing and associated bioinformatic pipelines for our studies of cancer evolution in human tissues. These interactions have taken our research in new directions!”

James DeGregori
Courtenay C. and Lucy Patten Davis Endowed Chair in Lung Cancer Research
Department of Biochemistry and Molecular Genetics,
University of Colorado Anschutz Medical Campus School of Medicine

Put Duplex Sequencing to work for you.

To get started, click “contact us” below to tell us about your current work and to learn how our Duplex Sequencing technology will revolutionize your research.


TwinStrand Biosciences, Inc.
3131 Elliott Ave, Suite 750 • Seattle, WA 98121 • USA
+1 (877) 202-TWIN

For Research Use Only. Not for use in diagnostic procedures.

©2022 TwinStrand Biosciences, Inc. All rights reserved. All trademarks are the property of TwinStrand Biosciences, Inc. or their respective owners.  Legal Notices


American Society of Hematology (ASH)

December 5-8, 2020 – Virtual

Poster Presentation

“Duplex Sequencing with Patient-Specific Hybrid Capture Panels Reveals Ultra-Low Frequency Measurable Residual Disease in Pediatric Acute Myeloid Leukemia”

Presented by Jake Higgins, Senior Scientist – December 6, 2020 7:00 a.m.-3:30 p.m. PST

Conference Website

Society of Toxicology (SOT)

March 10-14, 2019 – Baltimore, MD

Poster Presentations

View Poster

Conference Website

AACR Annual Meeting – San Diego, CA

March 29-April 3, 2019

Poster Presentations

View Poster

View Poster

Presentations by CEO Jesse Salk, MD, PhD – AGBT 2020

Ultra-Sensitive Residual Leukemia Detection with Patient-Specific Dupex Sequencing

TAGS:end to solution TwinStrand

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