Food For Breast Cancer | Food for Breast Cancer

Time 2021-09-16 10:29:52

Web Name: Food For Breast Cancer | Food for Breast Cancer

WebSite: http://foodforbreastcancer.com

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Food for Breast Cancer provides information on how various foods and other factors affect breast cancer risk, prevention and prognosis. The findings are drawn exclusively from scientific studies and updated as new research becomes available. Our goal is to provide breast cancer patients, survivors and those at high risk for breast cancer with information to help prevent and survive breast cancer. Study: Advances and challenges in cancer treatment and nutraceutical prevention: the possible role of dietary phenols in BRCA regulation Cite Khan H, Labanca F, Ullah H, Hussain Y, Tzvetkov NT, Akkol EK, et al. Advances and challenges in cancer treatment and nutraceutical prevention: the possible role of dietary phenols in BRCA regulation.Phytochemistry Reviews. Springer Science and Business Media LLC; 2021; 10.1007/s11101-021-09771-3Proteins encoded by BRCA tumor suppressor genes (BRCA1 and BRCA2) are used to repair damaged DNA, thereby preserving chromosome integrity during cell division. Defects in this process can cause mutation carriers to have relatively high lifetime risks of developing breast, ovarian and some other cancers.Some foods and food components have been shown to counteract the effects of detrimental BRCA mutations (please see Foods to eat and avoid for BRCA1 and BRCA2 carriers). Now a new review has summarized the potential roles of dietary polyphenols in counteracting the effects of BRCA1 and BRCA2 mutations. Polyphenols are plant-based micronutrients that may contribute to the color, smell or taste of foods. Examples include curcumin and resveratrol.Latest research outlines how diet can modify BRCA expressionThe review referenced above was designed to examine the role of dietary polyphenols in modifying BRCA gene expression. Such polyphenols can have an important role in pathways involved in cancer progression, influencing the expression of proteins encoded by oncogenes such as p27, p21, p53 and the two BRCA tumor suppressor genes. These genes have roles in apoptosis (programmed cell death), cell cycle arrest (halting progression through the cell cycle), inhibition of proliferation (preventing cell growth and cell division), which in turn promote cancer suppression.Polyphenols targeting BRCA genesIn the review, the authors discuss the polyphenols below, all of which have been shown to beneficially modify the expression of BRCA genes or appear to have the potential to do so. Epigenetic modifications (alterations in gene expression not caused by changes in the underlying DNA) are the primary mechanisms for influencing BRCA gene expression.CurcuminGenistein, daidzen & equolIndole-3-carbinol KaempferolQuercetinResveratrolThe authors conclude that increasing BRCA gene expression by polyphenols might be a useful strategy in cancer treatment, although the evidence is still limited and further studies are needed.Please click on any of the polyphenols listed above for important foods that incorporate significant levels, as well as related studies and news stories. Risk of Late-Onset Breast Cancer in Genetically Predisposed Women Cite Boddicker NJ, Hu C, Weitzel JN, Kraft P, Nathanson KL, Goldgar DE, et al. Risk of Late-Onset Breast Cancer in Genetically Predisposed Women.Journal of Clinical Oncology. American Society of Clinical Oncology (ASCO); 2021;:JCO.21.00531 10.1200/jco.21.00531 Consumption of reused vegetable oil intensifies BRCA1 mutations Cite Rajendran P, Alzahrani AM, Rengarajan T, Veeraraghavan VP, Krishna Mohan S. Consumption of reused vegetable oil intensifies BRCA1 mutations.Critical Reviews in Food Science and Nutrition. Informa UK Limited; 2020;:1-8 10.1080/10408398.2020.1837725 Isoflavone intake on the risk of overall breast cancer and molecular subtypes in women at high risk for hereditary breast cancer Cite Sim EJ, Ko K, Ahn C, Park SM, Surh Y, An S, et al. Isoflavone intake on the risk of overall breast cancer and molecular subtypes in women at high risk for hereditary breast cancer.Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2020; 184:615-626 10.1007/s10549-020-05875-0 Alcohol Consumption, Cigarette Smoking, and Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Results from The BRCA1 and BRCA2 Cohort Consortium Cite Li H, Terry MB, Antoniou AC, Phillips K, Kast K, Mooij TM, et al. Alcohol Consumption, Cigarette Smoking, and Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Results from The BRCA1 and BRCA2 Cohort Consortium.Cancer Epidemiology Biomarkers & Prevention. American Association for Cancer Research (AACR); 2019; 29:368-378 10.1158/1055-9965.epi-19-0546 Curcumin induces DNA damage by mediating homologous recombination mechanism in triple negative breast cancer Cite Guney Eskiler G, Sahin E, Deveci Ozkan A, Cilingir Kaya OT, Kaleli S. Curcumin induces DNA damage by mediating homologous recombination mechanism in triple negative breast cancer.Nutrition and Cancer. Informa UK Limited; 2019; 72:1057-1066 10.1080/01635581.2019.1670216 The Effect of Green and Black Tea Polyphenols on BRCA2 Deficient Chinese Hamster Cells by Synthetic Lethality through PARP Inhibition Cite Alqahtani S, Welton K, Gius J, Elmegerhi S, Kato T. The Effect of Green and Black Tea Polyphenols on BRCA2 Deficient Chinese Hamster Cells by Synthetic Lethality through PARP Inhibition.International Journal of Molecular Sciences. MDPI AG; 2019; 20:1274 10.3390/ijms20061274 A Dietary Intervention to Lower Serum Levels of IGF-I in BRCA Mutation Carriers Cite Pasanisi P, Bruno E, Venturelli E, Morelli D, Oliverio A, Baldassari I, et al. A Dietary Intervention to Lower Serum Levels of IGF-I in BRCA Mutation Carriers.Cancers. MDPI AG; 2018; 10:309 10.3390/cancers10090309 Physical activity during adolescence and young adulthood and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers Cite Lammert J, Lubinski J, Gronwald J, Huzarski T, Armel S, Eisen A, et al. Physical activity during adolescence and young adulthood and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.Breast Cancer Research and Treatment. Springer Science and Business Media LLC; 2018; 169:561-571 10.1007/s10549-018-4694-1 Abstract 2544: Association between flame-broiled fish consumption and breast cancer: A case-control study in women with high familial risk Cite Kaushiva A, May B, Armstrong D, Axilbund J, Visvanathan K. Abstract 2544: Association between flame-broiled fish consumption and breast cancer: A case-control study in women with high familial risk.Epidemiology. American Association for Cancer Research; 2016; 10.1158/1538-7445.am2016-2544

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