Unconventional Magnetic Resonance Techniques | Pines Lab

Time 2020-09-11 20:04:19

Web Name: Unconventional Magnetic Resonance Techniques | Pines Lab

WebSite: http://pines.berkeley.edu

ID:43570

Keywords:

Resonance,Magnetic,Unconventional,

Description:

Optically Detected NMR The power of NMR is in its chemical specificity, but it is by nature an insensitive technique, often requiring high sample concentrations and lengthy averaging time. In this work, we seek to couple the unique specificity of NMR with the sensitivity of optical detection.Learn More » Remote Detection Applying NMR methods to systems in which the spin density is low has been the major challenge precluding its more widespread use in applications on the micro-length scale where sample volumes are in the nanoliter or even picoliter range. In this project, new applications of NMR and MRI are developed for assaying small-volume samples of natural or synthetic origin. Learn more » Ultra Low-Field to Zero-Field NMR Counter to intuition, high magnetic fields are not necessarily required for high-resolution nuclear magnetic resonance. Furthermore, performing experiments in the absence of magnetic fields allows for a more "natural" spectroscopic state, governed by symmetries that are significantly different from those in high-field NMR. Learn more » Hyperpolarization Many projects in the Pines group are focused on developing methods of signal enhancement for magnetic resonance techniques through overcoming the poor nuclear polarization that is inherent to NMR. Hyperpolarizing methods not only stand to improve current technology, but also to broaden the scope of magnetic resonance capabilities. Learn More » Solid State NMR High frequency magic-angle spinning methods, multidimensional dipolar recoupling pulse sequences, and improved sample preparation techniques have made SSNMR a promising technique for atomic-resolution structure determination of proteins involved in a wide range of disorders and human diseases. Learn more » About Alex Pines Alexander Pines was born in 1945. He grew up in Rhodesia (now Zimbabwe) where his lifelong passion for science, music and chess was fostered. He then went to Israel to study mathematics and chemistry at the Hebrew University of Jerusalem, graduating with a B.Sc. in 1967. In 1968, Alex came to MIT, where he obtained his Ph.D. in chemical physics in 1972 and joined the Berkeley Faculty in the same year. He was promoted to Associate Professor in 1975 and to Professor in 1980. He is the Glenn T. Seaborg Professor Emeritus and Professor of the Graduate School at Berkeley, Affiliate Scientist Lawrence Berkeley National Laboratory and a Faculty Affiliate at QB3, California Institute for Quantitative Biomedical Research. More » About Our People The Pines Lab is made up of a diverse group of graduate students from the UC Berkeley Department of Chemistry, Department of Chemical Engineering, Department of Physics, Department of Bioengineering, and Biophysics Graduate Group. More » Current Pinenuts   Alumni Sign-In Pines is a pioneer in the development and applications of nuclear magnetic resonance (NMR) spectroscopy.  In his early work, he demonstrated time-reversal of dipole-dipole couplings in many-body spin systems, and introduced cross-polarization high resolution NMR of dilute spins such as carbon-13 in solids, thereby helping to launch the era of modern solid-state NMR in chemistry. He also developed the areas of multiple-quantum spectroscopy, zero-field NMR, double rotation and dynamic-angle spinning. His combination of optical pumping and cross-polarization made it possible to observe enhanced NMR of surfaces and the selective "lighting up" of solution NMR and magnetic resonance imagining (MRI).  His current program is composed of two complementary components. The first is the establishment of new concepts and techniques in NMR and MRI, in order to extend their applicability and enhance their capability to investigate molecular structure, organization and function from nanometers to meters in systems ranging from materials to organisms. Examples of methodologies emanating from these efforts include: novel spin polarization and detection methods, ex situ and mobile NMR and MRI, laser-polarized and detected NMR and MRI, functionalized NMR biosensors and molecular imaging, ultralow and zero-field NMR and MRI, and miniaturization of NMR and MRI onto microfluidic chips. The second component of his research program involves the application of such novel methods to problems in chemistry, materials science, and biomedicine.

TAGS:Resonance Magnetic Unconventional 

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