Wu Lab of Mechanistic Immunology | HMS/BCH
Time 2020-11-06 13:05:22Web Name: Wu Lab of Mechanistic Immunology | HMS/BCH
WebSite: http://wulab.tch.harvard.edu
ID:106859
Keywords:
of,Lab,Wu,HOME,ORGANIZERDescription:
2017-2020 Publications2017-2020 Publications2017-2020 PublicationsTHE WU LABMechanistic ImmunologyHomeResearchMembersPublicationsGalleryContact Welcome toThe Wu LabThe Wu laboratory of mechanisticimmunology focuses on elucidating cellular and structural regulation in innate immune pathways, in particular the inflammasome pathway.Our ResearchNewsCongratulations to Venkat and Roberto for theirrecent Science paper, "HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation"September 2020 | PDF |"Inflammasomes are supramolecular complexes that play key roles in immune surveillance. This is accomplished by the activation of inflammatory caspases, which leads to the proteolytic maturation of interleukin 1β (IL-1β) and pyroptosis. Here, we show that nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containg protein 3 (NLRP3)- and pyrin-mediated inflammasome assembly, caspase activation, and IL-1β conversion occur at the microtuble-organizing center (MTOC)."Continue ReadingCongratulations to Jacob and Shiyu for their recent Nature Immunology paper,"FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation""Inflammation is the alarm system by which cells first respond to potential danger, but in excess, inflammation can be fatal.In COVID-19, for example, overactive inflammation has led to severe complications and even death for many hospitalized patients.Research in mice led by Harvard Medical School and Boston Children’s Hospital now reveals that the FDA-approved drug disulfiram, commonly used for treating alcoholism, blocks a key gatekeeper protein involved in inflammation."Continue readingMay 2020| PDF | HMS News ResearchArticleCongratulations to Humayun, Li, and Weili for their recent Nature paper,"Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome"June 2019 | PDF | Nature News Views Feature Article"The NLRP3 inflammasome can be activated by stimuli that include nigericin, uric acid crystals, amyloid-β fibrils and extracellular ATP. The mitotic kinase NEK7 licenses the assembly and activation of the NLRP3 inflammasome in interphase. Here we report a cryo-electron microscopy structure of inactive human NLRP3 in complex with NEK7, at a resolution of 3.8 Å. The earring-shaped NLRP3 consists of curved leucine-rich-repeat and globular NACHT domains..."Continue readingSwell Snapshots | Harvard Medical School News Research"After decades of attempts by the scientific community, researchers at Harvard Medical School and Peking University have provided the first clear look at a protein implicated in a vast array of inflammatory conditions. The finding, published June 12 in Nature, lifts a blindfold that has hampered scientists' ability to intervene when the immune system overreacts to perceived threats..."Continue ReadingJune 2019 | PDF | HMS News Research ArticlesRead All NewsResearch<<< Thank you for your visit >>>
The Hao Wu laboratory of Mechanistic Immunology at Harvard Medical School/Boston Children's HospitalWebsites to related : Home - Prescriptiongiant
PrescriptionGiant is a FREE prescription savings program that can save you up to 75% on your prescriptions with or without insurance! PrescriptionGia
poetry of China | poetry of ChinThe Shih Ching , usually translated as either The Book of Songs or the Classic of Poetry, is the first great collection of Chinese poetry. Tradition s
Amaravati: Abode of Amritasfuka 'large shark' has nothing to do with the Chinesemorpheme 'dried fish' (Mandarin xiǎng, Cantonese soeng2,etc.) that 鱶 originally represented. Wh
Science: University of WaikatoAbout usThe School of Science is home to some of the most well-respected researchers in the science community. Our researchers - your lecturers - are
Theatre Guild Valdosta - ValdostDear Theatre Guild Valdosta community,Due to the spike in COVID-19 cases, Theatre Guild Valdosta has made the difficult decision to suspend its 32nd s
Local Band Network - HomeInformation about local bands and local music venues... no matter where "local" is to you. What's local for you? Going on a trip? Just get back from
Home | Mercy HousingLearn how we’re responding to COVID-19 and how you can help.This is an anxious time for everyone, and we are committed to supporting communities, res
University Housing | Housing | UUniversity Housing implemented a COVID-19 plan to best address the move-in and residential experience on campus. We've taken a number of steps this
Armurerie Pascal - Armurier en l-7% avec le code promo PASCAL7 (Hors promotions et catégorie B - code à durée limitée)
India At A Glance | A Glimpse OfIndia is acknowledged as one of the largest nations in Indian subcontinent that shares its boundaries with Myanmar and Bangladesh in the east, Bhutan
adsHot Websites