Journal of Cell Biology | Rockefeller University Press

Time 2020-09-18 02:03:43

Web Name: Journal of Cell Biology | Rockefeller University Press

WebSite: http://jcb.rupress.org

ID:50471

Keywords:

Cell,of,Journal,

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JCB staff members are working remotely in line with New York City s efforts to contain COVID-19. While our offices are physically closed, editorial and publication operations continue. JCB staff can be reached via email and phone, as we tend to our family, friends and community. Thank you for your patience and understanding.Journal of Cell Biology (JCB) seeks a talented individual for the role of Scientific Editor or Senior Scientific Editor, dependent on experience. Learn more Anjaneyulu Murari, Shauna-Kay Rhooms, Naga Sri Goparaju, Maximino Villanueva, Edward Owusu-Ansah During mitochondrial complex I (CI) assembly, independently formed assembly intermediates (AIs) merge with each other to form the mature complex. Murari et al. generate a toolbox of 21 antibodies to various mitochondrial proteins and use classical Drosophila genetics and immunoblotting of AIs to define AIF’s role in CI biogenesis. Maria Casas, Rut Fadó, José Luis Domínguez, Aina Roig, Moena Kaku, Shigeru Chohnan, Montse Solé, Mercedes Unzeta, Alfredo Jesús Miñano-Molina, José Rodríguez-Álvarez, Eamonn James Dickson, Núria Casals GuA1-containing AMPA receptors play a key role in synaptic plasticity and cognition. Casas et al. demonstrate that the sensing of nutrients by CPT1C regulates the phosphatase activity of SAC1, and consequently PI(4)P levels, at the contact sites between the endoplasmic reticulum and the trans-Golgi network to control the trafficking of GluA1 receptors to the cell surface of neurons. Elizabeth A. Allen, Clelia Amato, Tina M. Fortier, Panagiotis Velentzas, Will Wood, Eric H. Baehrecke Allen et al. identify a conserved role for dMtmr6/CG3530 and MTMR8 in regulating autophagic flux. Decreased dMtmr6 function results in autophagic vesicle accumulation, influences endolysosomal homeostasis, and is required for Drosophila development. Michel Becuwe, Laura M. Bond, Antonio F.M. Pinto, Sebastian Boland, Niklas Mejhert, Shane D. Elliott, Marcelo Cicconet, Morven M. Graham, Xinran N. Liu, Olga Ilkayeva, Alan Saghatelian, Tobias C. Walther, Tobias C. Walther, Robert V. Farese, Jr., Robert V. Farese, Jr. FIT2 is a protein important for ER lipid metabolism and lipid droplet formation, but its function has remained mysterious. Becuwe et al. show that FIT2 is an acyl coenzyme A diphosphatase, and this activity is crucial for ER homeostasis and cellular lipid storage. Shubham Kesarwani, Prakash Lama, Anchal Chandra, P. Purushotam Reddy, A.S. Jijumon, Satish Bodakuntla, Balaji M. Rao, Carsten Janke, Ranabir Das, Minhajuddin Sirajuddin Intracellular nanobodies as fluorogenic sensors have been developed for many cellular components. Here, we report tyrosination sensor, the first genetically encoded sensor against tyrosinated microtubules. The sensor described here has potential applications to study microtubules and their PTMs in living cells. Masayuki Ozawa, Sylvain Hiver, Takaki Yamamoto, Tatsuo Shibata, Srigokul Upadhyayula, Yuko Mimori-Kiyosue, Masatoshi Takeichi During the collective migration of epithelial cells, interior cells produce “cryptic” lamellipodia to advance. Ozawa et al. show that formation of cryptic lamellipodia is regulated by WAVE and Arp2/3 complexes that accumulate at the adherens junctions. Without this system, cells lose control of their migration. Liz J. Valente, Amy Tarangelo, Albert Mao Li, Marwan Naciri, Nitin Raj, Anthony M. Boutelle, Yang Li, Stephano Spano Mello, Kathryn Bieging-Rolett, Ralph J. DeBerardinis, Jiangbin Ye, Scott J. Dixon, Laura D. Attardi Using oncogene-expressing cells to interrogate p53 function under physiological oxygen conditions, Valente et al. show that p53 deficiency drives concurrent dysregulation of a range of cellular processes. These findings highlight the pleiotropic effects of p53 inactivation.Subscribe to RSS headline updates from: Powered by FeedBurner Centromeres, loci driving chromosome segregation, are marked epigenetically by H3 variant CENP-A. In this review, Mitra et al. discuss the mechanisms of faithful CENP-A inheritance. Killackey et al. review recent advances and major questions in the field of mitophagy, as well as implications for mitophagy in disease. Gliech and Holland discuss the guiding design principles of biological clocks across a variety of model systems. This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.

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Journal of Cell Biology (JCB) publishes advances in any area of basic cell biology as well as applied cellular advances in fields such as immunology, neurobiology, metabolism, microbiology, developmental biology, and plant biology. Est. 1955

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