Home | Cancer Immunology Research
Time 2021-01-02 03:04:51Web Name: Home | Cancer Immunology Research
WebSite: http://cancerimmunolres.aacrjournals.org
ID:153650
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Cancer,Home,Research,Description:
The AACR remains fully committed to supporting publishing operations throughout this challenging time, while still remaining flexible and supportive of the author, reviewer, and editor communities that we serve. If you have any questions or concerns, please reach out to a member of the AACR publishing staff.Please visit the COVID-19 Cancer Resource Center where COVID-related content is freely available. Research Articles | AuthorChoice Tumor Cell–Derived TGFβ1 Attenuates Antitumor Immune Activity of T Cells via Regulation of PD-1 mRNA Pengfei Wu, Bo Geng, Qun Chen, Enyang Zhao, Jiang Liu, Chen Sun, Caijun Zha, Yong Shao, Bosen You, Wenfu Zhang, Lulu Li, Xiangqi Meng, Jinquan Cai and Xuedong Li Cancer Immunol Res December 1 2020 8 (12) 1470-1484; DOI:10.1158/2326-6066.CIR-20-0113 TGFβ1 is shown to regulate PD-1 expression, thereby modulating CD8+ T-cell responses in clear-cell renal cell carcinoma (ccRCC). By targeting this regulatory mechanism, antitumor responses are boosted. The data highlight an immune evasion strategy used by ccRCC. Research Articles Treatment of Multiple Myeloma Using Chimeric Antigen Receptor T Cells with Dual Specificity Anat Globerson Levin, Moran Rawet Slobodkin, Tova Waks, Galit Horn, Lihi Ninio-Many, Naamit Deshet Unger, Yaara Ohayon, Shimrit Suliman, Yael Cohen, Boris Tartakovsky, Ella Naparstek, Irit Avivi and Zelig Eshhar Cancer Immunol Res December 1 2020 8 (12) 1485-1495; DOI:10.1158/2326-6066.CIR-20-0118 CAR T cells mostly induce nondurable and nonspecific responses in multiple myeloma (MM). The creation of a dual CAR with split configuration targeting two MM-associated antigens has better specificity and superior antitumor activity than single target CAR T cells. Research Articles Idelalisib Rescues Natural Killer Cells from Monocyte-Induced Immunosuppression by Inhibiting NOX2-Derived Reactive Oxygen Species Ali A. Akhiani, Alexander Hallner, Roberta Kiffin, Ebru Aydin, Olle Werlenius, Johan Aurelius, Anna Martner, Fredrik B. Thorén and Kristoffer Hellstrand Cancer Immunol Res December 1 2020 8 (12) 1532-1541; DOI:10.1158/2326-6066.CIR-20-0055 Idelalisib, a PI3Kδ inhibitor, inhibits antibody-induced formation of ROS in human monocytes by preventing Akt-dependent phosphorylation of NOX2. By rescuing NK cells from immunosuppressive ROS, idelalisib promotes NK cell–mediated antibody-dependent cellular cytotoxicity against malignant B cells.<<< Thank you for your visit >>>
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