Gladskin HCP

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The Gladskin difference.

Gladskin is the first endolysin-based cream that repairs the skin microbiome imbalance associated with eczema while providing the benefits of an emollient without corticosteroids. 

Learn More

Peter Lio, MD
Assistant Clinical Professor of
Dermatology & Pediatrics, Northwestern
National Eczema Association
Scientific Advisory Board Member

Skin Microbiome: The key to treating eczema flares

While the role of the Staphylococcus aureus in eczema flares is well understood in the medical community, there have never been options to target it long term without resistance while sparing the commensal bacteria. (Kong et al, Genome Res. 2012)

Eczema flare severity is correlated with high Staphyloccous colonization and low microbial diversity

Time (Atopic Dermatitis disease progression)

Microbial diversityDisease severityProportion Staphylococcus

Benefits of Gladskin with Micreobalance® Endolysin


Read in-vitro results regarding targeted activity against S. aureus.


Preserves the protective commensal bacteria, including S. epidermidis.


Endolysin is not expected to induce resistance based on in-vitro study results.

Hear from our Scientific Advisory Board

Play Video Close

Peter Lio, MD

Board-Certified Dermatologist
Assistant Clinical Professor of Dermatology & Pediatrics, Northwestern University School of Medicine

Play Video Close

Richard Antaya, MD

Board-Certified Dermatologist

Professor of Dermatology, Yale School of Medicine

Director, Pediatric Dermatology, Yale Dermatology Associates

Clinical Results - Journal of Drugs in Dermatology December 2021

Read published research demonstrating significant improvement in eczema symptoms and QoL for patients after treatment with Gladskin’s patented Endolysin ingredient

Additional Research

Dysbiosis and Staphyloccus aureus Colonization Drives Inflammation in Atopic Dermatitis


Ecology of eczema


Staphefekt – intervening early in the Colonisation Infection Continuum with endolysins


Prevalence and odds of Staphylococcus aureus carriage in atopic dermatitis: a systematic review and meta -analysis


Staphylococcus aureus and Staphylococcus epidermidis strain diversity underlying pediatric atopic dermatitis


The bacterial culprit that drives atopic dermatitis | National Eczema Association


Staphylococcus δ-toxin promotes mouse allergic skin disease by inducing mast cell degranulation


Gladskin has a robust safety profile 

Gladskin has been on the market in Europe since 2016 without concerning adverse event reports*Ingredients: Water, Glycerin, Petrolatum, Mineral Oil, Cetearyl Alcohol, Ceteareth-20, Arginine HCl, Sodium Chloride, Colloidal Oatmeal, Tromethamine, Calcium Chloride, Micreobalance®Now Gladskin Eczema Cream is manufactured in a cGMP FDA registered manufacturing facility in the U.S.Safety demonstrated in a placebo controlled trial of patients with Eczema (n=100)Passed 21 Day Cumulative Irritation Test (n=51)Passed Repeated Insult Patch Testing on sensitive skin panel (n=57)Passed phototoxicity panel test (n=22)

Gladskin has been used safely throughout Europe since 2016

German Eczema Patient Study of self-reported outcomes after using Gladskin (European formula) demonstrated 76% of people experienced improvement within a few days.

Speed and degree of response to Gladskin among total

*Study performed on Gladskin Eczema Cream in Europe

Speed and degree of response to Gladskin among responders

*Study performed on Gladskin Eczema Cream in Europe

Instructions for patient and caretaker use

Gladskin with Micreobalance® is available for use without prescription by adults and children 3 months and up.Use Gladskin twice a day, or more as desired, on skin free of other products.Wait at least 5 minutes after applying Gladskin before applying other topical products.There are no known contraindications. Gladskin can be used alongside corticosteroids and other topical and systemic treatments.

This page is intended for Healthcare Professionals.

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