Journal of Cell Biology (JCB) | Rockefeller University Press

Time 2021-04-28 11:07:46

Web Name: Journal of Cell Biology (JCB) | Rockefeller University Press

WebSite: http://jcb.rupress.org

ID:172854

Keywords:

Cell,Biology,Journal,

Description:

Pal et al. discover that podosomes and invadopodia ubiquitously recruit membrane-bound DNase X, which readily degrades extracellular double-stranded DNA. The authors also show that macrophages, in response to immunogenic materials, form podosomes that degrade bacterial DNA on surfaces. Geng-Yuan Chen, Fioranna Renda, Huaiying Zhang, Alper Gokden, Daniel Z. Wu, David M. Chenoweth, Alexey Khodjakov, Michael A. Lampson Chen et al. show how kinetochores integrate mechanics and biochemistry using optogenetic manipulation of Aurora B kinase. Aurora B promotes microtubule depolymerization at low tension or microtubule release at high tension. Thus, tension is a signal inducing distinct error-correction pathways. Heather A. Baldwin, Chunxin Wang, Gil Kanfer, Hetal V. Shah, Antonio Velayos-Baeza, Marija Dulovic-Mahlow, Norbert Brüggemann, Allyson Anding, Eric H. Baehrecke, Dragan Maric, William A. Prinz, Richard J. Youle The VPS13 proteins (VPS13A–D) are thought to mediate lipid transport between organelles and are linked to distinct neurological disorders in humans. Baldwin et al. found that, in addition to known involvement in mitochondrial morphology, VPS13D is essential for peroxisome biogenesis. Andrés Guillén-Samander, Marianna Leonzino, Michael G. Hanna, IV, Ni Tang, Hongying Shen, Pietro De Camilli VPS13D mutations result in severe mitochondrial defects. Guillén-Samander et al. show that VPS13D binds VAP in the ER and interacts with Miro on mitochondria and peroxisomes, where it could provide a bridge for lipid transport between these organelles. Shanna L. Bowman, Linh Le, Yueyao Zhu, Dawn C. Harper, Anand Sitaram, Alexander C. Theos, Elena V. Sviderskaya, Dorothy C. Bennett, Graça Raposo-Benedetti, David J. Owen, Megan K. Dennis, Michael S. Marks Bowman et al. show that in melanocytes, the vSNARE VAMP7 is sorted from endosomes into tubular membrane transport carriers bound for maturing melanosomes in a complex with the tSNARE syntaxin 13 via redundant recognition of each SNARE by an AP-3–BLOC-1 super-complex. Centromeric transcription is critical for proper centromere function, but its exact role remains elusive. By manipulating the activity of centromeric transcription, Chen et al. report that a major function of centromeric transcription in human cells is to maintain centromeric cohesion. Thaddaeus Mutugi Nthiga, Birendra Kumar Shrestha, Jack-Ansgar Bruun, Kenneth Bowitz Larsen, Trond Lamark, Terje Johansen Nthiga et al. identify CALCOCO1 as a receptor for autophagic degradation of Golgi during nutrient starvation. CALCOCO1 binds the Golgi-resident palmitoyltransferase ZDHHC17 and ATG8 family proteins to facilitate Golgiphagy to control Golgi size. Depletion of CALCOCO1 causes expansion of the Golgi and accumulation of its structural and membrane proteins.Subscribe to RSS headline updates from: Powered by FeedBurner McQuown et al. highlight work from Culver and Mariappan that reveals that tail-anchored (TA) proteins are correctly targeted and inserted into the ER membrane despite being polyubiquitinated. Hamidi and Ivaska preview work from the Korolchuk laboratory describing focal adhesions as hubs mediating growth factor signaling via mTORC1 and amino acid input into the cell. This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.

TAGS:Cell Biology Journal 

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Journal of Cell Biology (JCB) publishes advances in any area of basic cell biology as well as applied cellular advances in fields such as immunology, neurobiology, metabolism, microbiology, developmental biology, and plant biology. Est. 1955

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