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One-pot Synthesis of (R)- and (S)-Phenylglycinol from L-Phenylalanine by an Artificial Biocatalytic Cascade

Chiral phenylglycinol is a very important chemical in the pharmaceutical manufacturing. The present research considered a six-step artificial cascade biocatalysis system for the conversion of bio-based l-phenylalanine into chiral phenylglycinol using a microbial consortium including two engineered recombinant E. coli cells, one co-expressed six different enzymes for efficient conversion of l-phenylalanine into 2-hydroxyacetophenone, while another E. coli cell expressed an (R)-蠅-transaminase or co-expressed the (S)-蠅-transaminase, alanine dehydrogenase and glucose dehydrogenase for the conversion of 2-hydroxyacetophenone into (S)- or (R)-phenylglycinol, respectively. Combining the two engineered E. coli cells, l-phenylalanine could be easily converted into (R)-phenylglycinol and (S)-phenylglycinol with up to 99% conversion and 鈥?/strong>99% ee without additional cofactor (NADH/NAD⁺).

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Aims and scope

Bioresources and Bioprocessing (BIOB) is a peer-reviewed open access journal published under the brand SpringerOpen.聽BIOB aims at providing an international academic platform for exchanging views on and promoting research to support bioresource development, processing and utilization in a sustainable manner. As an application-oriented research journal,聽BIOB covers not only the application and management of bioresource technology but also the design and development of bioprocesses that will lead to new and sustainable production processes.

BIOB聽publishes original and review articles on most topics relating to bioresource and bioprocess engineering, including:

Biochemical and microbiological engineeringBiocatalysis and biotransformationBiosynthesis and metabolic engineeringBioprocess and biosystems engineeringBioenergy and biorefineryCell culture and biomedical engineeringFood, agricultural and marine biotechnologyBioseparation and biopurification engineeringBioremediation and environmental biotechnology Recent News First JCR Impact Factor: 4.578 The Top 10 Most Cited Articles in BIOB (2018-2020) An Interview with Prof. Tingyue Gu, Associate Editor of Bioresources of Bioprocessing Call for Papers : Special Issue on Bioresources and Bioprocessing

Call for Papers

Bioenergy锛?/strong>A Sustainable Solution for Carbon Neutrality

A Special Issue of Bioresources and Bioprocessing for

WBS2021: The 12^th International Bioenergy Symposium

(http://wbs2021.csp.escience.cn)

Guest Editors: Dehua Liu, Xuebing Zhao, Wei Du, Zhen Chen

Bioresources and Bioprocessing (BIOB) plans to publish a Special Issue with the subject of 鈥?strong>Bioenergy锛?/strong>A Sustainable Solution for Carbon Neutrality鈥? This special issue is in liaison with the 12th International Bioenergy Symposium (WBS2021, http://wbs2021.csp.escience.cn), which will be held in Nanning, China during 19鈥?1 November 2021. All the participants of this exciting symposium are cordially invited to submit their original research articles including rapid communications or mini-reviews to this open-access but free-of-charge journal which is published by the Springer Nature group and sponsored by the State Key Laboratory of Bioreactor Engineering (China). The Impact Factor of this China-based and SCI-indexed biotechnology journal is rapidly increasing, with an Impact Factor of 4.578 as of 2020.

Both reviews and research articles are welcome. The topics of interest include, but are not limited to:

Status and prospect of biofuels Policy and market of biofuels Fuel ethanol technology (1st and 2nd generation) Systems biology and metabolic engineering for biofuels and biomass-based chemicals Metabolic modeling and simulation for biofuels and biomass based chemicals Biodiesel technology Pretreatment and bioconversion of biomass Biobased polymers and materials Biorefining technology LCA of biofuels

All papers and supplementary information (if any) should be submitted online (http://www.bioresourcesbioprocessing.com/) and prepared according to the BIOB guidelines (http://bioresourcesbioprocessing.springeropen.com/submission-guidelines). Authors should indicate that the paper is submitted for the special issue in their cover letter and is not published or being considered to publish elsewhere. All submissions will be subject to peer review before possible acceptance for publication in BIOB which is now free of charge and highly accessed/cited by readers from all over the world.

The date open for submission to the WBS2021 Special Issue: From Now On;

Until the deadline: December 15, 2021.

Bioresources and Bioprocessing is associated with theState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology鈥嬧€嬧€嬧€嬧€嬧€嬧€?

Speed
40days to first decision for reviewed manuscripts only
36days to first decision for all manuscripts
105 days from submission to acceptance
10 days from acceptance to publication

Citation impact
4.578 -2-year Impact Factor
1.746 -Source Normalized Impactper Paper (SNIP)
1.053 -SCImago Journal Rank (SJR)

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