Cardiology Online - International Academy of Cardiology

Time 2020-10-23 01:05:28

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International Academy of Cardiology Annual Scientific Sessions 2022 24th World Congress on Heart Disease Boston, MA, USA July 2022 CME Meeting Preliminary List of Scientific Presentations is online. “Innovations in Treatment of Heart Disease”: A Complimentary Scientific CME Webinar from the Smidt Heart Institute at Cedars-Sinai:Wednesday, October 21, 2020, 5:00-6:30 PM PST On Behalf of Drs. Asher Kimchi and Daniel S. Berman, Medical Directors of the Preventive and Consultative Heart Center of Excellence, Smidt Heart Institute, Cedars-Sinai Medical Center, we would like to invite you to join a complimentary scientific CME Webinar: “Innovations in Treatment of Heart Disease” to be held on Wednesday, October 21, 2020, at 5:00 PM – 6:30 PM, Pacific Daylight Time (San Francisco, GMT – 07:00). This complimentary scientific CME program is geared towards health care professionals. If you would like to register and to receive a WebEx URL link to join the event, please email your request to marietta.coquia@cshs.org, indicating your full name, place of work, city and country, by Tuesday, October 20, 2020. Program: “Innovations in Treatment of Heart Disease” Welcome Asher Kimchi, MD and Daniel S. Berman, MD, Medical Directors, P&C Heart COE, Smidt Heart Institute, Cedars-Sinai Medical Center “Coronary CTA in 2020” Matthew J. Budoff, MD, PhD, Program Director and Director of Cardiac CT, Division of Cardiology, Harbor-UCLA Medical Center “Transcatheter Tricuspid Valve Replacement” Raj R. Makkar, MD, Director, Interventional Cardiology Division, Smidt Heart Institute, Cedars-Sinai; Vice President, Cardiovascular Innovation and Intervention, Cedars-Sinai Medical Center “Novel Therapeutic Approaches to Heart Failure” Barry Greenberg, MD, Director, Advanced Heart Failure Treatment Program at the University of California Health, San Diego “Minimally Invasive and Robotic Cardiac Surgery Review” Danny Ramzy, M.D. Ph.D, Surgical Director, Lung Transplant Program, Smidt Heart Institute, Cedars-Sinai; Director, Robotic & Minimally Invasive Cardiac Surgery, Smidt Heart Institute “The Leadless Pacemaker and Other Innovations in Pacing” Michael M. Shehata, MD, Director, Pacemaker and Defibrillator Clinic; Director, Clinical Cardiac Electrophysiology Fellowship Training, Smidt Heart Institute, Cedars-Sinai Medical Center THE FIGHT AGAINST COVID-19 INFECTION WebinarStay on top of the rapidly growing body of scientific knowledge. Watch a recording from a live Webinar held on 4/29/2020, The Fight Against COVID-19 Infection . This educational session of the Preventative and Consultative (P C) Heart Center of Excellence (COE), Smidt Heart Institute, Cedars Sinai Medical Center, was chaired by Asher Kimchi, M.D., and Daniel S. Berman, M.D., Medical Directors of the P C Heart COE, Smidt Heart Institute. PROGRAM: Covid-19 and the Heart Eduardo Marban, MD, PhD Executive Director, Smidt Heart Institute Interleukin-6 inhibitors for Treatment of Cytokine Storm in COVID-19 Patients Stanley Jordan, MD Director, Division of Nephrology and Kidney Transplant Program Antiviral Therapy for Patients with COVID-19 Infection Victor Tapson, MD Co-Director, Pulmonary Hypertension Program Cardiosphere-Derived Cells (CDCs) in Severe COVID-19 Siddharth Singh, MD Assistant Director, Echo Fellowship Training Program, Smidt Heart Institute Immune Therapies for Covid-19 Noah M. Merin, MD, PhD Division of Hematology/Oncology To access the video, click here. Then, click on Content Tests and Launch Video. Video from the 16th World Congress on Heart Disease International Academy of CardiologyAnnual Scientific Sessions 201823rd World Congress on Heart Disease The Westin Copley PlaceBoston, MA, USA July 27 - 29, 2018 CME Meeting Photo Gallery Presented abstracts have been published in a special online supplement issue of the journal CARDIOLOGY published by S. Karger AG, Basel, Switzerland. International Academy of Cardiology Annual Scientific Sessions 2017 22nd World Congress on Heart Disease The Hyatt Regency Vancouver Vancouver, BC, Canada July 14 - 16, 2017 CME Meeting Photo Gallery Presented abstracts have been published in a special online supplement issue of the journal CARDIOLOGY published by S. Karger AG, Basel, Switzerland. International Academy of Cardiology Annual Scientific Sessions 2016 21st World Congress on Heart Disease The Westin Copley Place Boston, MA, USA July 30 - August 1, 2016 CME Meeting Photo Gallery International Academy of CardiologyAnnual Scientific Sessions 201520th World Congress on Heart Disease Hyatt Regency Vancouver Vancouver, BC, Canada July 25-27, 2015 CME Meeting Photo Gallery International Academy of Cardiology Annual Scientific Sessions 2014 19th World Congress on Heart Disease Hyatt Regency, Boston, MA, USA July 25-28, 2014 CME Meeting Photo Gallery International Academy of Cardiology 18th WORLD CONGRESS ON HEART DISEASE Annual Scientific Sessions 2013 July 26-29, 2013 Hyatt Regency, Vancouver, BC, Canada CME Meeting Photo Gallery Photos from the 18th World Congress on Heart Disease (click here to see more photos) To see more information on Previous IAC Meetings, click here. Invited Speaker Presentations at the IAC Annual Scientific Sessions 2017, 22nd World Congress on Heart Disease, Boston, MA, USA (click on the photo to view the video) VASCULOPROTECTIVE ROLE OF NATRIURETIC PEPTIDE RECEPTOR C Madhu B. Anand-Srivastava, Ph.D., University of Montreal, Montreal, Quebec, Canada VSMC from spontaneously hypertensive rats (SHR) exhibit enhanced proliferation and hypertrophy. We earlier showed that small peptide fragments of cytoplasmic domain of natriuretic receptor-C (NPR-C) attenuate vasoactive peptide-induced hyperproliferation and hypertrophy of VSMC, the key players of vascular remodeling. MORE REVASCULARIZATON IN PATIENTS WITH DIABETES MELLITUS: OPTIMAL APPROACH IN 2017 Gregory W. Barsness, M.D., Mayo Clinic, Rochester, MN, USA Background: Diabetes mellitus is a growing worldwide problem, affecting 28 million patients in the US, with another 80 million at risk due to obesity and related disorders. Diabetes mellitus is associated with significant health and social costs, with an estimated annual economic toll of $322 billion dollars in the US. MORE Distinguished Cardiologists and Scientists Honored with 2018 International Academy of Cardiology Awards at the 23rd World Congress on Heart Disease, Boston, MA, USA Dr. Asher Kimchi, Founder and Chairman of the International Academy of Cardiology (IAC) announced the winning recipients of the 2018 IAC Awards at the 23rd World Congress on Heart Disease held in Boston, MA, USA. In addition to the IAC awards, the committee also named four faculty to receive the Distinguished Fellowship Awards. Dr. Asher Kimchi, together with Chairman Dr. Dr. John A. Elefteriades, headed a committee comprised of 222 of the world's leading cardiologists and scientists that reviewed a prestigious list of nominees and voted for their top choice. The following awards for 2018 were presented at the Opening Ceremony of the International Academy of Cardiology Annual Scientific Sessions 2018, 23rd World Congress on Heart Disease, to honor the memory of distinguished colleagues, all former members of the faculty of previous International Academy of Cardiology meetings who made major contributions to Medicine and Cardiology: MORE Dr. Deepak Bhatt to Deliver Opening Lecture at International Academy of Cardiology, Annual Scientific Sessions 2018, 23rd World Congress on Heart Disease Deepak L. Bhatt MD, MPH, Executive Director of Interventional Cardiovascular Programs at Brigham and Women’s Hospital Heart & Vascular Center and Professor of Medicine at Harvard Medical School, Boston, MA, USA, delivered the Twelfth H.J.C. Swan Memorial Lecture at the Opening Ceremony of the International Academy of Cardiology, Annual Scientific Sessions 2018, 23rd World Congress on Heart Disease, that was held in Boston, MA, USA, from Friday, July 27 through Sunday, July 29, 2018. Dr. Bhatt presented on the topic of Evolving Landscape of Antithrombotic Therapy for Atherosclerosis . Aspirin remains the foundation of antiplatelet therapy. Trials soon to report will clarify its role in primary prevention. The role of aspirin in secondary prevention seems quite secure, though recent data have raised concerns about whether the enteric coating might impede its absorption and antiplatelet effects. MORE Distinguished Cardiologists and Scientists Honored with 2017 International Academy of Cardiology Awards at the 22nd World Congress on Heart Disease, Vancouver, BC, Canada Dr. Asher Kimchi, Founder and Chairman of the International Academy of Cardiology (IAC) announced the winning recipients of the 2017 IAC Awards at the 22nd World Congress on Heart Disease held in Vancouver, BC, Canada. In addition to the IAC awards, the committee also named four faculty to receive the Distinguished Fellowship Awards. Dr. Asher Kimchi, together with Co-Chairmen Dr. Jeffrey S. Borer and Dr. John A. Elefteriades, headed a committee comprised of 191 of the world's leading cardiologists and scientists that reviewed a prestigious list of nominees and voted for their top choice. The following awards for 2017 were presented at the Opening Ceremony of the International Academy of Cardiology Annual Scientific Sessions 2017, 22nd World Congress on Heart Disease, to honor the memory of distinguished colleagues, all former members of the faculty of previous International Academy of Cardiology meetings who made major contributions to Medicine and Cardiology: MORE Dr. Anne B. Curtis Delivered Opening Lecture at International Academy of Cardiology, Annual Scientific Sessions 2017, 22nd World Congress on Heart Disease Anne B. Curtis, M.D., SUNY Distinguished Professor and Charles and Mary Bauer Professor and Chair of the Department of Medicine at the University at Buffalo, New York, USA, delivered the eleventh H.J.C. Swan Memorial Lecture at the Opening Ceremony of the International Academy of Cardiology, Annual Scientific Sessions 2017, 22nd World Congress on Heart Disease, that was held in Vancouver, BC, Canada, from Friday, July 14 through Sunday, July 16, 2017. Dr. Curtis presented on the topic of “Improvement in Quality of Care for Atrial Fibrillation in Get with the Guidelines – Atrial Fibrillation (GWTG-AFIB)”. MORE Dr. Eugene Braunwald Delivered the 10th HJC Swan Memorial Lecture at the Opening Ceremony of the International Academy of Cardiology, Annual Scientific Sessions 2016, 21st World Congress on Heart Disease Eugene Braunwald, M.D., Distinguished Hersey Professor of Medicine at Harvard Medical School, and founding Chairman of the TIMI Study Group at the Brigham and Women’s Hospital, Boston, Massachusetts, USA, delivered the tenth H.J.C. Swan Memorial Lecture at the Opening Ceremony of the International Academy of Cardiology, Annual Scientific Sessions 2016, 21st World Congress on Heart Disease, that was held in Boston, MA, USA, from Saturday, July 30 through Monday, August 1, 2016. Dr. Braunwald presented on the topic of “The War on Heart Failure”. MORE Click here to view Cardiology Online News articles on Opening Lectures. Click here to view more Cardiology Online News articles on Opening Ceremony of the IAC Annual Scientific Sessions and presentation of the IAC Awards. Click here to view Invited Speaker Presentation Videos from Previous Meetings Invited Speaker Presentations at the IAC Annual Scientific Sessions 2016, 21st World Congress on Heart Disease, Boston, MA, USA (click on the photo to view the video) THE PRESENT AND FUTURE OF THE TOTAL ARTIFICIAL HEART Francisco Arabia, M.D., Cedars-Sinai Medical Center, Los Angeles, CA, USA We aim to better understand the pt population with biventricular failure receiving TAH as a BTT, determine outcomes in 3 eras, effect of implanting ctr on outcomes, and adverse events related to this therapy. MORE 2016 UPDATE ON TREATMENT OF HYPERTENSION Wilbert S. Aronow, M.D., Westchester Medical Center/New York Medical College, Valhalla, NY, USA Numerous guidelines from 2011 through 2015 except for JNC 8 recommended that the blood pressure (BP) goal should be DELIRIUM IN THE INTENSIVE CARE UNIT: MORE THAN A NUISANCE Gregory W. Barsness, M.D., Mayo Clinic, Rochester, MN, USA Regardless of the underlying condition and comorbidities, along with pain and agitation, delirium is a common condition with major impact on the care and outcome of patients requiring intensive care unit (ICU) hospitalization. MORE ACELLULAR BIOLOGICS FOR CARDIAC REGENERATION Atta Behfar, Ph.D., Mayo Clinic, Rochester, MN, USA The global drive to generate new curative therapies is fueled by a growing unmet perpetuated by the heart failure pandemic. Regenerative trials in cardiovascular disease have focused on the use of cell-based therapy in acute myocardial injury, in order to halt progression towards heart failure, or in congestive heart failure, to regenerate a deteriorating myocardium. MORE PET AND CT ASSESSMENT OF CORONARY FLOW PHYSIOLOGY Daniel S. Berman, M.D., Cedars-Sinai, Los Angeles, California USA Assessment of fractional flow reserve (FFR) and coronary flow reserve by invasive coronary angiography provide physiologic assessments that complement the anatomic assessment of coronary stenosis for guiding patient management of patients with coronary artery disease. MORE CONTROVERSIES IN ANTIPLATELET AND ANTICOAGULANT THERAPY Deepak L. Bhatt, M.D., Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA Antiplatelet therapy is critical for patients with acute coronary syndromes, those undergoing coronary stenting, and especially for patients with both indications. Aspirin continues to be the backbone of antiplatelet strategies in cardiovascular secondary prevention. MORE PLAQUE LYMPHANGIOGENESIS: TO DRAIN OR NOT TO DRAIN Erik A. L. Biessen, Ph.D., Maastricht University, Maastricht, Netherlands Vulnerable plaques are hallmarked by more pronounced inflammation and neoangiogenesis. Although angiogenesis and lymphangiogenesis are driven by partly overlapping cues, and especially under inflammatory conditions go hand in hand, plaque lymphangiogenesis only in one single earlier report been linked to plaque stability. MORE TICAGRELOR AND STATIN HAVE SYNERGISTIC EFFECTS ON MYOCARDIAL PROTECTION AGAINSY ISCHEMIA-REPERFUSION INJURY Yochai Birnbaum, M.D., Baylor College of Medicine, Houston, TX, USA In addition to P2Y12 receptor antagonism, ticagrelor (TIC) inhibits the equilibrative- nucleoside-transporter-1 and thereby, adenosine cell re-uptake. Prior data show that TIC limits infarct size in non-diabetic rats and that the effect is adenosine dependent. MORE PREVENTION OF SUDDEN CARDIAC DEATH: CHALLENGES AND OPPORTUNITIES Michael Cain, M.D., University at Buffalo, Buffalo, NY, USA Strategies for prevention of sudden cardiac death in the setting of coronary artery disease rely on implantable cardiac defibrillators (ICD) in a subset of patients with left ventricular ejection fractions EXERCISE RELATED HYPERTENSION (ERH) MAY NOT BE A BENIGN PHENOMENON Yzhar Charuzi, M.D., Cedars Sinai Medical Center, LA, USA Blood Pressure (BP) increases with exercise. However a Systolic BP reaching or exceeding 200mm Hg is considered pathological. We recently observed a 78 years old male who, while walking uphill suddenly noticed loss of speech. MORE PREVENTION AND INTERFERENCE OF ATHEROSCLEROTIC HEART DISEASE IN MULTIPLE ANIMAL MODELS Subroto Chatterjee, Ph.D., Johns Hopkins University, Baltimore, MD, USA We previously observed that the level of cholesterol and glycosphingolipids (GSL) rise and fall in tandem upon plasma exchange therapy in patients with LDL receptor negative homozygous familail hypercholesterolemia. MORE BIOMARKERS OF THE FUTURE: METABOLOMIC PREDICTORS OF CARDIOMETABOLIC DISEASE Susan Cheng, M.D., Brigham and Women's Hospital, Boston, MA, USA By providing information on the diversity of small molecule metabolites in biological systems, current era metabolomics now offer the potential to comprehensively integrate data on both the intrinsic and extrinsic exposures that contribute to complex diseases such as cardiovascular disease. MORE RISK STRATIFICATION AND THERAPY OF ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY Domenico Corrado, M.D., Ph.D., University of Padova, Italy Arrhythmogenic Right Ventricular Cardiomyopathy is a genetically determined cardiomyopathy which predisposes to life-threatening ventricular arrhythmias and arrhythmic cardiac arrest. The main goal of clinical management is prevention of sudden cardiac death. MORE IMPROVEMENT IN CLINICAL OUTCOMES WITH BIVENTRICULAR VERSUS RIGHT VENTRICULAR PACING IN THE BLOCK HF STUDY Anne B. Curtis, M.D., University of Buffalo, Buffalo, NY, USA Sustained right ventricular (RV) apical pacing may lead to deterioration in ventricular function and an increased risk of heart failure, especially in patients with pre-existing systolic dysfunction. MORE SHORT AND LONG NON-CODING RNAs AS BIOMARKERS OF ACUTE CARDIAC CONDITIONS Yvan Devaux, Ph.D., Luxembourg Institute of Health, Luxembourg The first draft of the human genome was published in 2001. However, it is only 10 years later that the ENCODE Int'l Consortium revealed that, while more than 80% of the human genome is transcribed into RNAs, only less than 2% of these RNAs are subsequently translated into proteins. MORE PATHOGENESIS AND THERAPY OF DIABETIC CARDIOMYOPATHY Naranjan S. Dhalla, Ph.D., M.D. (Hon.), St. Boniface Hospital Albrechtsen Research Centre, University of Manitoba, Winnipeg, MB, Canada Chronic diabetes is known to be associated with the development of cardiomyopathy, metabolic derangement and cardiac dysfunction. Extensive studies in our laboratory have revealed that cardiac dysfunction due to chronic diabetes is associated with marked alterations in subcellular organelles such as myofibrils, sarcoplasmic reticulum and sarcolemma. MORE CARDIAC IMAGING FOR EVALUATION OF CORONARY ARTERY DISEASE IN PATIENTS WITH HYPERTENSION Abdou Elhendy, M.D., Ph.D., Marshfield Clinic, Marshfield, WI, USA Hypertension is a major risk factor for coronary artery disease (CAD) and related morbidity. Identification of an accurate non-invasive method for diagnosis of CAD is important to plan therapeutic and interventional management in order to improve outcome. MORE HIGH-SENSITIVITY ASSAY FOR CARDIAC TROPONIN: NOVEL TOOLS FOR RISK PREDICTION IN AMBULATORY PATIENTS Brendan M. Everett, M.D., Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA Assays for cardiac troponin have become increasingly sensitive, and are now able to detect very low concentrations of circulating cardiac troponin in a substantial proportion of stable patients who are not suspected of having myocardial infarction. MORE CpG DNA REGULATION OF COAGULATION: IMPLICATIONS FOR ACUTE CORONARY ARTERY DISEASE Janos G. Filep, M.D., University of Montreal, Montreal, Quebec, Canada Bacteraemia is associated with increased risk of acute coronary artery disease and stroke. Bacterial DNA and mitochondrial DNA, containing unmethylated CpG dinucleotide motifs are potent inducers of immune responses during infection MORE HYPERTENSION UPDATE: QUO VADIMUS? Zorina S. Galis, Ph.D., Vascular Biology and Hypertension, National Heart Lung and Blood Institute, Bethesda, MD, USA Hypertension continues to represent a formidable challenge to human health and to healthcare worldwide. Exciting new developments in clinical and fundamental hypertension research are poised to change how we understand and approach the clinical management of hypertension. MORE COMPUTED TOMOGRAPHY ANGIOGRAPHY VS. CORONARY ANGIOGRAPHY: A 3D VESSEL FEATURE COMPARISON AND VALIDATION Joel Garcia, M.D., Orlando Health, Orlando, FL, USA Differences in vessel features between computed tomography angiograms (CTA) and coronary angiograms have not been rigorously studied, therefore we sought to validate CTA 3-dimensional (3D) vessel data against coronary angiography MORE ROLE OF ECHOCARDIOGRAPHY IN EPIDEMIOLOGIC STUDIES AND CLINICAL TRIALS: AN HISTORICAL PERSPECTIVE Julius M. Gardin, M.D., Hackensack University Medical Center, Rutgers New Jersey Medical School, NJ, USA Non-invasive transthoracic echocardiography (TTE) for assessment of subclinical and clinical heart disease – initially, left ventricular (LV) mass, geometry and function – dates from the 1980’s. In parallel, TTE successfully demonstrated in hypertensive patients reduced LV mass and improved outcomes MORE THYROID HORMONE TREATMENT OF HEART FAILURE: IS THERE A THERAPEUTIC WINDOW? A. Martin Gerdes, Ph.D., New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, USA In 1950, a study showed that Thyroid Hormone (TH) treatment significantly reduced cardiovascular mortality and rates of myocardial infarction in three patient groups. Rather than extend these findings, subsequent poorly designed larger clinical studies using toxic doses of TH analogs MORE THE CENTRAL ROLE OF SMOOTH MUSCLE CELL MITOCHONDRIA IN THE PREVENTION OF ABDOMINAL AORTIC ANEURYSM BY LOW LEVEL LASER THERAPY S. David Gertz, M.D., Ph.D., The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel We showed, by high frequency ultrasound, that phototherapy with low-level laser, a non-thermal, near-infrared radiation, used widely for reduction of pain and acceleration of wound healing, prevents de novo formation and progression of pre-existing abdominal aortic aneurysm MORE UPDATE ON ASPIRIN IN THE PRIMARY PREVENTION OF CARDIOVASCULAR DISEASE Charles H. Hennekens, M.D., Dr.P.H., Florida Atlantic University, Boca Raton, FL, USA In secondary prevention among a wide range of patients who have survived a prior occlusive vascular event, as well as during acute myocardial infarction and acute occlusive stroke the absolute reductions far exceed the absolute risks. In primary prevention, tbe balance is less clear. MORE IMPACT OF EXERCISE CAPACITY FOR RIGHT AND LEFT HEART FAILURE Akihiro Hirashiki, M.D., Nagoya University School of Medicine, Nagoya, Japan Cardiopulmonary exercise testing is a diagnostic tool used to detect serial changes in exercise capacity, and it is of particular benefit for patients with chronic heart failure to assess peak oxygen uptake (peak VO2) and minute ventilation/carbon dioxide production (VE/VCO2) slope. MORE ATRIAL FUNCTIONAL MITRAL REGURGITATION: THE LEFT ATRIUM GETS ITS DUE RESPECT Brian D. Hoit, M.D., University Hospitals Case Medical Center, Case Western Reserve University. Cleveland, OH, USA Moderate or greater mitral regurgitation (MR) is the most frequent valve disease in the United States. Competence of the mitral valve requires the temporally and spatially coordinated interaction of the mitral leaflets with the annulus, chordae tendinae, and papillary muscles; MORE INITIAL STAGES OF OBESITY ARE ASSOCIATED WITH INCREASED CARDIOVASCULAR ACTIVATION UNDER STRESS Daniella Jezova, M.D., Slovak Academy of Sciences, Bratislava, Slovakia Stress and obesity are well known risk factors for cardiovascular diseases. The recognition of early markers of cardiovascular risk during the development of obesity is essential. The hypothesis tested was that under stress conditions subjects at initial stages of obesity MORE ATRIAL FUNCTIONAL MITRAL REGURGITATION: MACROPHAGE DEPOSITION OF CHOLESTEROL INTO THE EXTRACELLULAR MATRIX - A PATHWAY FOR REVERSE CHOLESTEROL TRANSPORT Xueting Jin, M.D., National Institutes of Health, Bethesda, Maryland, USA To investigate the potential for mobilization of extracellular cholesterol within atherosclerotic plaques. Background: Atherosclerotic plaques develop as a result of an imbalance between cholesterol accumulation and cholesterol removal. MORE THE BENEFITS AND RISKS OF LEFT VENTRICULAR ASSIST DEVICE IMPLANTATION; WHERE IS THE POINT OF CLINICAL EQUIPOISE? Maryl R. Johnson, M.D., University of Wisconsin, Madison, WI, USA Left ventricular assist devices (LVADs) are used to treat patients with severe heart failure, both as a bridge to transplantation and as destination therapy. However, the best time to proceed with LVAD implantation remains to be determined. MORE AGING AND HEART FAILURE 2016. UPDATE Bodh I. Jugdutt, M.D., University of Alberta, Edmonton, Alberta, Canada Concurrent worldwide increases in the aging population and prevalence of heart failure (HF) are accompanied by a parallel increase in the elderly (age = 65 years) with two leading causes of HF, hypertension and myocardial infarction. MORE TRANSITION TO STAGE D HEART FAILURE AMONG STABLE OUTPATIENTS WITH SYSTOLIC HEART FAILURE Andreas P. Kalogeropoulos, M.D., Ph.D., Emory University, Atlanta, GA, USA Incidence rates and risk factors for transition to Stage D heart failure (HF) among patients with stable, Stage C HF with reduced ejection fraction have not been described. Methods: We evaluated 3-year transition rates to clinically determined Stage D HF, after accounting for competing mortality, in 919 outpatients MORE TRANSULNAR INTERVENTIONS Edo Kaluski, M.D., Guthrie Health System, PA, USA The use of transradial access for diagnostic and therapeutic interventions has dramatically increased in the recent years and has become the preferred approach for coronary angiography and intervention. The ulnar artery is similar in diameter however is somewhat deeper MORE THE ROLE OF ECHOCARDIOGRAPHY IN THE MANAGEMENT OF PATIENTS UNDERGOING VENTRICULAR ASSIST DEVICE IMPLANTATION AND/OR TRANSPLANT SURGERY Tomoko S. Kato, M.D., Ph.D. , Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan Heart transplantation (HTx) is a curative treatment for patients with advanced heart failure; however, since transplant opportunity is severely limited due to donor shortage, left ventricular assist device has evolved into a standard therapy for patients awaiting HTx. MORE TREATING FLUID OVERLOAD WITH FLUID; ROLE OF PERITONEAL DIALYSIS IN MANAGEMENT OF HEART FAILURE Amir Kazory, M.D., University of Florida, Gainesville, Florida, USA Heart failure (HF) remains the most common reason for hospital admission in older patients resulting in significant burden on healthcare expenditure. The currently available therapeutic modalities for HF do not seem yet to be producing optimal results. MORE THE USE OF POINT OF CARE ULTRASOUND TO GUIDE MANAGEMENT IN HEART FAILURE Ilan Kedan, M.D., Cedars Sinai Heart Institute, Beverly Hills, CA, USA Point of Care ultrasound has long been used in the acute care and emergency setting for management of trauma patients. MORE EDUCATION AND MORTALITY: IS A COLLEGE DEGREE UNIVERSALLY PROTECTIVE? Arthur L. Klatsky, M.D., Kaiser Permanente Division of Research, Oakland, CA, USA To study risk of death in relation to educational attainment in 273,843 persons. Background: Low socio-economic status has been associated with increased incidence of many medical conditions and connected to racial and ethnic health disparities. MORE EFFECT OF ENDOTHELIAL CELL SENESCENCE ON THE HEAT SHOCK RESPONSE AND CELLULAR FUNCTION Anne. A. Knowlton, M.D., Sacramento VA Medical Center, Mather, CA USA and University of California, Davis, CA, USA Increasing evidence supports that replicative senescence, cessation of cell division, plays a role in the progression of the aging phenotype. With cellular senescence, cells undergo morphologic, physiologic and functional changes. MORE DOES CYSTATIN SN INFLUENCE ON CYSTATIN C LEVEL IN ISCHEMIA AND PREVIOUS MYOCARDIAL INFARCTION? Tatiana A. Korolenko, Ph.D., Institute Physiol. Fund. Med., Novosibirsk, Russia Objectives: To investigate whether patients with ischemic heart disease and previous myocardial infarction (MI) display altered serum cystatin C/cystatin SN ratio. MORE CURRENT STATUS OF INTRAVASCULAR IMAGING Santhosh K.G. Koshy, M.D., University of Tennessee Health Sciences Center, Memphis TN, USA Diagnostic angiography has been the mainstay of confirmatory diagnosis of vascular atherosclerosis. Being a luminogram its ability to determine the presence and extent of atherosclerosis is limited by changes in the vessel wall that is adjacent to the atherosclerotic plaque. MORE ROLE OF CVD RISK ASSESSMENT IN COPD Hwa Mu Lee, M.D., University of California, Irvine, Irvine, CA, USA Chronic obstructive pulmonary disease is commonly associated with cardiovascular disease since they are both linked with shared factors such as age and smoking history; however, in clinical practice, these two diseases are treated separately. MORE DECIPHERING THE ROLE OF MITOPHAGY IN THE HEART DURING FASTING Qiangrong Liang, M.D., Ph.D., New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, USA Alternate-day fasting or starvation is beneficial to the heart, but the underlying mechanism remains speculative. Starvation activates general autophagy, which may contribute to the cardioprotective effect of fasting. MORE AVOIDING AND SOLVING COMPLICATIONS DURING PERCUTANEOUS CLOSURE OF ASD Avraham Lorber, M.D., Rambam Medical Campus, Haifa, Israel We present 11 cases of percutaneous transcatheter occlusion of atrial septal defects in adults. These select cases represent an educational approach to special dilemmas, complications, and challenges MORE GLYCOSAMINOGLYCANS (GAGS) IN CARDIOVASCULAR DISEASE: SEARCHING FOR THE SWEET SPOT Alexandra R. Lucas, M.D., University of Florida, Gainesville, FL, USA The endothelial glycocalyx alters immune reactions. Among other functions, glycosaminoglycans in the glycocalyx bind chemokines that attract immune cell invasion. MORE TRANSLATING VASCULAR BIOLOGY INTO CLINICAL CARE FOR CARDIOLOGY Kenneth Maiese, M.D., Rutgers University of Medicine & Dentistry of New Jersey With the progressing aging of the world’s population, cardiovascular disease will continue to significantly impact millions of individuals throughout the globe. This disorder remains one of five leading causes of death that are cardiac disease, cancer, MORE A NANOMEDICAL APPROACH TO THE RESTORATION OF DYSFUNCTIONAL ENDOTHELIUM AND THE FUNCTION OF THE CARDIOVASCULAR SYSTEM Tadeusz Malinski, Ph.D., Ohio University, Athens, OH, USA A dysfunctional endothelium is a common denominator in aging and several cardiovascular diseases: hypertension, diabetes, salt-induced hypertension and atherosclerosis. MORE CLINICAL GENETICS OF DILATED CARDIOMYOPATHY- TESTING WISELY James D. Marsh, M.D., University of Arkansas for Medical Sciences, Little Rock, AR, USA Dilated cardiomyopathies (DCM) account for 10,000 deaths/year in the US; African-Americans have a 3-fold increased risk. There has been little solid information available on or the ability to make a precise genetic diagnosis in DCM. MORE WHAT HAPPENS TO THE BRAIN AFTER MYOCARDIAL INFARCTION? Jawahar L. Mehta, M.D., Ph.D. , University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR, USA It is assumed, but not proven, that acute myocardial infarction affects function of remote organs- such as kidneys and brain. We examined brain morphology in wild type (WT) mice subjected to left coronary artery (LCA) ligation. MORE OPTIONS FOR REMOTE PATIENT MONITORING IN THE LVAD POPULATION Dan M. Meyer, M.D., Methodist Health System, Dallas, Texas, USA Multiple technologies are emerging that may have roles in remote patient monitoring in the LVAD population. These include smartphone applications and wearables, nanosensors, lab-on-a-chip platforms, and miniaturized systems. MORE SECONDARY PREVENTION OF CARDIOVASCULAR EVENTS Samia Mora, M.D., Brigham and Women's Hospital, Boston, MA, USA Cardiovascular risk among individuals with manifest cardiovascular disease remains high and has been termed residual risk . Results from a meta-analysis of statin trials involving 90,056 individuals found that the rate of a major vascular event MORE UPDATE ON CONTRAST REMOVAL FROM CORONARY SINUS DURING CORONARY ANGIOGRAPHY OR INTERVENTION FOR PREVENTION OF CONTRAST INDUCED NEPHROPATHY Mohammad-Reza Movahed, M.D., Ph.D., CareMore, Tucson, Arizona, University of Arizona College of Medicine, USA Contrast usage during coronary angiography or intervention in patients with renal disease is associated with substantial risk of contrast induced nephropathy that can lead to higher mortality, longer hospital stay and substantial cost. MORE CAN GDF-15 BE USED AS A BIOMARKER IN DILATED CARDIOMYOPATHY Nandini Nair, M.D., Ph.D., Texas Tech HSC, Lubbock, TX, USA Growth and Differentiation Factor-15 (GDF-15) has been found to play an important role in fibrosis, inflammation and ventricular remodeling. The role of GDF-15 in regulation of cardiac remodeling in idiopathic dilated cardiomyopathy is less well-defined. MORE INNOVATIVE P-WAVE DETECTION FOR DISCRIMINATION BETWEEN VENTRICULAR AND SUPRAVENTRICULAR TACHYCARDIA IN SINGLE-CHAMBER ICDS: IS THE P-WAVE INVISIBLE DURING TACHYCARDIA? Hakan Paydak, M.D. , UAMS, Little Rock, AR, USA Differentiation between supraventricular tachycardia and ventricular tachycardia remains a substantial clinical challenge in patients with single-chamber implantable cardioverter-defibrillators due to absence of visible P waves. MORE LOW GRADIENT SEVERE AORTIC STENOSIS: ECHO FEATURES AND CLINICAL SIGNIFICANCE Patricia A. Pellikka, M.D., Mayo Clinic, Rochester, MN, USA Current practice guidelines define severe aortic stenosis (AS) as aortic valve (AV) area less than1 cm2 and mean AV gradient greater than 40 mmHg. Low gradient severe AS refers to the condition of mismatch between an AV area which suggests severe AS and mean gradient MORE VALVE PROSTHESIS-PATIENT MISMATCH (VP-PM): A LONG-TERM PERSPECTIVE Shahbudin H. Rahimtoola, M.D., University of Southern California, Los Angeles, CA, USA VP- PM was first described in 1978 by Rahimtoola. From that time to 2011, aortic VP-PM has received a great deal of attention but studies have come to varying conclusions especially with regard to its effect on mortality. MORE OSTEOGENIC DIFFERENTIATION IS A MECHANISM FOR BIOPROSTHETIC VALVE CALCIFICATION Nalini M. Rajamannan, M.D., Mayo Clinic, Rochester, MN, USA Bioprosthetic heart valve calcification is the major cause of structural valve deterioration (SVD). The mechanism of valve degeneration is unknown. This study hypothesizes that bioprosthetic valve calcification is a stem cell mediated bone differentiation process. MORE THE HIGHLY DIFFICULT LIPOPROTEIN: CONTROVERSIES AND NEW DIRECTIONS Robert S. Rosenson, Ph.D., Icahn School of Medicine at Mount Sinai, New York, NY, USA Classical epidemiology has established the incremental contribution of the high density lipoprotein (HDL) cholesterol measure in the assessment of atherosclerotic cardiovascular disease risk; however, genetic epidemiology does not support a causal relationship between HDL cholesterol and future risk of myocardial infarction. MORE CXCR6/CXCL16 AXIS IS INVOLVED IN MONONUCLEAR CELL ADHESION INDUCED BY ANGIOTENSIN II, POTENTIAL IMPLICATION IN ABDOMINAL AORTIC ANEURYSM (AAA) FORMATION? Maria J. Sanz, Ph.D., Faculty of Medicine, University of Valencia, Valencia, Spain Abdominal aortic aneurysm is a degenerative disease of the aorta that mainly affects elderly population over the age of 65. Nowadays the pathways involved in its onset and progression remain unknown and angiotensin-II has been widely implicated. MORE CARDIOVASCULAR EFFECTS OF CARFILZOMIB, A NEW PROTEASOME INHIBITOR, ON CORONARY ARTERY RESISTANCE, VASCULAR TONE AND VASCULAR REACTIVITY Tiziano M. Scarabelli, M.D., The University of Alabama at Birmingham, Birmingham, AL, USA Carfilzomib is a proteasome inhibitor which was recently approved in the United States as a single agent for the treatment of patients with relapsed and refractory Multiple Myeloma. Chemically it is a tetrapeptide epoxyketone and an analog of epoxomicin. MORE COMPARISON OF EARLY HEMODYNAMIC PERFORMANCE OF STENTED PERICARDIAL AND PORCINE AORTIC VALVES Rakesh K. Sharma, M.D., University of Utah, Salt Lake City, UT, USA Data comparing the hemodynamic performance of stented pericardial and porcine aortic valves are conflicting. We performed a systematic review and meta-analysis comparing the early hemodynamic parameters of stented pericardial and porcine valves in patients undergoing isolated aortic valve replacement. MORE ASTHMA AS A RISK FACTOR OF HUMAN AND EXPERIMENTAL ABDOMINAL AORTIC ANEURYSM Guo-Ping Shi, SC.D., D.SC., Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA Asthma and abdominal aortic aneurysms (AAA) both involve inflammation. It remains unknown whether these diseases interact. MORE THE CANCER ASSOCIATED FIBROBLAST AND THE HEART FAILURE ASSOCIATED FIBROBLAST- SIMILAR PHENOTYPE, SIMILAR PATHWAYS LEADING TO POTENTIALLY SIMILAR TREATMENT Francis G. Spinale, Ph.D., M.D., USC School of Medicine and WJB Dorn VA, Columbia, SC, USA While morbidity, mortality, and health care costs associated with heart failure (HF) are increasing, advancements in early diagnosis and treatment strategies have not been forthcoming. Firstly, there is a need to differentiate HF phenotypes into different disease processes MORE RISK STRATIFICATION IN BRUGADA SYNDROME: ICD INDICATION IN PATIENTS WITHOUT HISTORY OF CARDIAC ARREST Masahiko Takagi, M.D., Ph.D., Osaka City Graduate School of Medicine, Osaka, Japan Risk assessment in patients without previous documented VF or aborted sudden death (SCD) is not yet fully established. Indication for implantable cardioverter defibrillator in Brugada patients without documented VF or SCD is classified as Class II or III indication. MORE OPTIMUM TREATMENT OF ANGINA PECTORIS SHOULD TAKE INTO CONSIDERATION PATIENTS’ CIRCULATORY STATUS AND THE PRESENCE OF ASSOCIATED COMORBIDITIES IN THE YEAR 2016 Udho Thadani, M.D., M.D., OU Medical Center and VA Medical Center, Oklahoma City, Oklahoma, USA Currently many treatment options, including medicines, and revascularization procedures are available to treat patients with stable angina pectoris. All patients with angina pectoris due to underlying CAD should be treated with a low dose aspirin and a high dose, potent statin, if tolerated, MORE PREVENTION OF ACUTE MI BY AGGRESSIVE APPROACH TO TREAT UNSTABLE ANGINA Yasunori Ueda, M.D., Ph.D., Osaka National Hospital, Osaka, Japan Although the incidence of in-hospital death from acute myocardial infarction (MI) is about 5%, about 40% of the patients who suffer acute MI die before hospitalization. MORE THE ROLE OF HEMODYNAMIC SUPPORT IN THE MANAGEMENT OF AMI WITH SHOCK George W. Vetrovec, M.D., VCU Medical Center Richmond, Virginia USA Outcomes for Acute Myocardial Infarction have improved significantly with acute Percutaneous Coronary Intervention. However, the incidence of associated cardiogenic shock has increased and remains a major cause of death. MORE SEX DIFFERENCES IN THE CARDIOVASCULAR CONSEQUENCES OF DIABETES MELLITUS Nanette K. Wenger, M.D., Emory University School of Medicine, Atlanta, GA, USA Cardiovascular disease is the leading cause of morbidity and mortality with type 2 diabetes mellitus, accounting for > 75% of hospitalizations and >5% of deaths. Women have a 3-fold excess of coronary heart disease risk compared to men MORE EFFICACY OF A CARDIOVASCULAR BEHAVIORAL INTERVENTION PROGRAM ON PROGRESSION OF ATHEROSCLEROSIS Nathan D. Wong, Ph.D., University of California, Irvine, CA, USA Limited data exist on the efficacy of multifactorial lifestyle programs on impacting the progression of atherosclerosis. We examined the efficacy of a lifestyle intervention program on progression of coronary artery calcium. MORE WHOLE HEART REGENERATION WITH HUMAN iPS CELL-DERIVED HEART PROGENITORS Lei Yang, Ph.D., University of Pittsburgh, Pittsburgh, PA, USA In US, about 50,000 people die each year due to the limited donor hearts for transplant. Thus the future treatment of heart disease requires the development of personalized therapeutic strategies, such as patient-specific cardiac tissues or whole bio-artificial hearts for transplantation. MORE

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