ZELNORM (tegaserod) IBS-C Prescription Medication for Patients | HCP Site

Web Name: ZELNORM (tegaserod) IBS-C Prescription Medication for Patients | HCP Site

WebSite: http://www.zelnormhcp.com






ZELNORM is the only prokinetic agent for IBS-C that stimulates serotonin receptors to normalize motility, reduce abdominal pain, and relieve bloating. Prescribe ZELNORM to address unmet needs in women under age 65 with IBS-C.1-5

See how ZELNORM is different from other prescription treatments for IBS-C
Learn how ZELNORM provides proven efficacy
Eligible patients can save on ZELNORM


ZELNORM (tegaserod) is indicated for the treatment of adult women less than 65 years of age with irritable bowel syndrome with constipation (IBS-C).

Important Safety Information

ZELNORM should be used in females under 65 years of age who do not have a history of ischemic cardiovascular disease and who have no more than one CVD risk factor. CVD risk factors are defined as active smoking, current hypertension/history of antihypertensive treatment, current hyperlipidemia/history of lipid-lowering medication, history of diabetes mellitus, age ≥55 years, or obesity (BMI >30 kg/m2).


ZELNORM is contraindicated in patients with:

History of myocardial infarction (MI), stroke, transient ischemic attack (TIA), or anginaHistory of ischemic colitis or other forms of intestinal ischemiaSevere renal impairment (eGFR< 15 mL/min/1.73 m2) or end-stage renal diseaseModerate and severe hepatic impairment (Child-Pugh B or C)History of bowel obstruction, symptomatic gallbladder disease, suspected sphincter of Oddi dysfunction, or abdominal adhesionsHypersensitivity to ZELNORM

Warnings and Precautions

Cardiovascular Ischemic Events, Including Major Adverse Cardiovascular Events (MACE): Stroke, MI, and cardiovascular death have been reported in adults taking ZELNORM who had an increased risk of developing an adverse cardiovascular event based on their medical history.

Female patients less than 65 years of age should be assessed for a history of cardiovascular disease and cardiovascular risk factors prior to treatment with ZELNORM.

Discontinue ZELNORM in patients who experience an MI, stroke, TIA, or angina. Evaluate the risks and benefits of continued use of ZELNORM in patients who develop evidence of cardiovascular ischemic heart disease (e.g., coronary artery disease) and/or experience changes in health status that could increase cardiovascular risk during treatment with ZELNORM.

Ischemic Colitis: Ischemic colitis and other forms of intestinal ischemia have been reported postmarketing in patients receiving ZELNORM. Discontinue ZELNORM in patients who develop symptoms of ischemic colitis, such as rectal bleeding, bloody diarrhea, or new or worsening abdominal pain.

Volume Depletion Associated with Diarrhea: In postmarketing experience, serious consequences of diarrhea including hypovolemia, hypotension, and syncope have been reported in patients treated with ZELNORM. Avoid use of ZELNORM in patients who are currently experiencing or frequently experience diarrhea. Instruct patients to discontinue ZELNORM and contact their healthcare provider if severe diarrhea, hypotension, or syncope occur.

Suicidal Ideation and Behavior: Monitor all ZELNORM-treated patients for clinical worsening of depression and emergence of suicidal thoughts and behaviors, especially during the initial few months of treatment. Counsel family members and caregivers of patients to monitor for changes in behavior and to alert the healthcare provider. Instruct patients to immediately discontinue ZELNORM and contact their healthcare provider if their depression is persistently worse or they are experiencing emergent suicidal thoughts or behaviors.

Common Adverse Reactions (incidence >2% and greater than placebo)

The most common adverse reactions in 3 placebo-controlled trials of ZELNORM in female IBS-C patients less than 65 years of age: headache (14% vs 10% placebo), abdominal pain (11% vs 10%), nausea (8% vs 7%), diarrhea (8% vs 3%), flatulence (6% vs 5%), dyspepsia (4% vs 3%), and dizziness (4% vs 3%).

Use in Specific Populations

Pregnancy: Safety and effectiveness not establishedLactation: Breastfeeding not recommendedPediatric use: Safety and effectiveness not establishedGeriatric use: Not indicated for patients 65 years of age and olderSevere renal conditions: ContraindicatedModerate to severe hepatic conditions: Contraindicated

Please click here for full Prescribing Information.

Indication and Important Safety InformationEXPANDEXPANDReferences: 1. ZELNORM (tegaserod) [package insert]. Covington, LA: Alfasigma USA, Inc. 2019. 2. AMITIZA (lubiprostone) [package insert]. Deerfield, IL: Takeda Pharmaceuticals America, Inc. 2018. 3. LINZESS (linaclotide) [package insert]. Madison, NJ: Allergan USA, Inc. and Cambridge, MA: Ironwood Pharmaceuticals, Inc. 2018. 4. TRULANCE (plecanatide) [package insert]. New York, NY: Synergy Pharmaceuticals Inc. 2018. 5. Quigley EMM. Prokinetics in the management of gastrointestinal disorders. J Neurogastroenterol Motil. 2015;21(3):330-336.

You are about to go to another site.

Do you want to leave this site?

Please verify that you are a U.S. Healthcare Professional

This information is intended for U.S. Healthcare Professionals

TAGS:IBS Prescription ZELNORM tegaserod

<<< Thank you for your visit >>>

Websites to related :


Accueil | Gibson

   Navigation principale - Fr

Lifts Group | CIBSE

   Skip to main content Login

Air Ribs

   1-800-247-7427 scottz@countyline.com

Jet Tender | Yacht Tenders | Jet

  Williams - Jet TendersOur range131+ft / 40+m Yachts Seats up to 1382+ft / 25+m Yachts Seats up to 1165+ft / 20+m Yachts Seats up to 740+ft / 12+m Yach

Buy Buspar Online | Buspar No Pr

  Buy Buspar OnlineCelexaKamagraLevothroidPepcidPrevacidValtrex Getting Rid Of Anxiety By Using BusparWorrying about pointless things and living in a

Prenatal Vitamins by Prescriptio


Abilify without a prescription

  Buy abilify online Meds Title &times;Abilify without a prescriptionGo to content Buy abilify online

AbilifyGeneric name: Aripiprazole

Software – Personalised Prescri

  Get 20% off Advanced Ageing Set with code: MOTHERSDAY20. Offer ends 8 May 11.59pm AEST.MenuMenuauau0Your Cart( items)Free express shipping on all orde

Noprescription Cialis Online &#

  Noprescription Cialis Online my body my healthy


Hot Websites