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Time 2020-11-17 09:03:06

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Thursday, November 26, 2020 - 11:30 - Thursday, November 26, 2020 - 12:30 Marlène DREUX, Centre International de Recherche en Infectiologie, Lyon, FRHost: Marc DALODReporté à une date ultérieure - Postponed to a… Mon 19/10/2020Le Laboratoire Européen de Biologie Moléculaire (EMBL) a signé un mémorandum d’entente pour renforcer sa collaboration avec le Centre d'Immunologie de Marseille-Luminy (CIML) Wed 30/09/2020Avec 86 000 nouveaux cas par an aux Etats-Unis et 18 000 en France, et des taux de mortalités quidemeurent élevés, le lymphome est un problème de santé publique. Sat 30/05/2020Philippe Pierre selected for the Sanofi Innovation Awards 2020His project has been selected for funding within iAwards Europe 2020 Program. This program in Europe helps to… FIRST PATIENT DOSED IN AVDORALIMAB PHASE II CLINICAL TRIAL IN COVID-19 PATIENTS WITH SEVERE PNEUMONIAInitial translational analysis, EXPLORE, showed overexpression of C5a/C5aR pathway in patients with severe COVID-19The primary objective of this investigator-sponsored trial, named FORCE, is to improve the proportion of COVID-19 patients with severe pneumonia who no longer need to be hospitalized, and to reduce the need for and duration of mechanical ventilation in patients with COVID-19 pneumonia complicated by acute respiratory distress syndrome (ARDS).“Through the translational data analysis in COVID-19 patients, we observed high levels of circulating C5a and over-activation of the C5a-dependent myeloid cell pathway, which is believed to contribute to inflammation in the lungs. Avdoralimab is a monoclonal antibody that blocks C5aR and has the potential to reduce the inflammatory response in the lungs,” said Pr. Eric Vivier, PhD, Chief Scientific Officer at Innate Pharma and Professor at AP-HM (Marseille Public University Hospitals), Aix-Marseille University and Centre d’Immunologie de Marseille-Luminy, CNRS, Inserm and AMU.More information A newly discovered memory in our bones: blood stem cells boost immunity by keeping a record of previous infectionsA Franco-German research team led by Prof. Michael Sieweke, from the Center for Regenerative Therapies TU Dresden (CRTD) and the Center of  Immunology of Marseille Luminy (CNRS, INSERM, Aix-Marseille University), today uncovered a surprising property of blood stem cells: not only do they ensure the continuous renewal of blood cells and contribute to the immune response triggered by an infection, but they can also remember previous infectious encounters to drive a more rapid and more efficient immune response in the future. These findings should have a significant impact on future vaccination strategies and pave the way for new treatments of an underperforming or over-reacting immune system. The results of this research are published in Cell Stem Cell on March 12, 2020. More informationC/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cellsde Laval B., Maurizio J., Kandalla P K., Brisou G., Simonnet L., Huber C., Gimenez G., Matcovitch-Natan O., Reinhardt S., David E., Mildner A., Leutz A., Nadel B., Bordi C., Amit I., Sarrazin S.*,†., Sieweke M H.*,†. Cell Stem Cell, 2020 , pii: S1934-5909(20)30017-5, PMID: 32169166When Stress Weakens the Immune DefensesIn previous years, various studies have established a link between psychological stress and reduced immune defenses, but the mechanisms involved remained poorly elucidated. Sophie Ugolini, Inserm Research Director at the Center of Immunology Marseille-Luminy, and her colleagues at CNRS and Aix-Marseille Université have recently shown that such a link is to a large extent mediated by a type of receptor that binds to stress hormones: the β2-adrenergic receptor. Their findings have been published in Journal of Experimental Medicine. More informationβ2-adrenergic signals downregulate the innate immune response and reduce host resistance to viral infection Wieduwild E, Girard-Madoux MJ, Quatrini L, Laprie C, Chasson L, Rossignol R, Bernat C, Guia S, Ugolini S. J Exp Med., 2020 , 217(4), PMID: 32045472 At the crossroads of biology and medicine, immunology is a scientific discipline that focuses on the operating mechanisms of the immune system. Appeared early in the evolution, this system enables living organisms to defend themselves against pathogens or their own components when they are altered. It involves a large number of cells whose capacity for cooperation, recognition and memory are far from having revealed all their secrets. Association of COVID-19 inflammation with activation of the C5a-C5aR1 axisCarvelli J, Demaria O, Vély F. et al., Nature., 2020, PMID: 32726800 LymphoAtlas: a dynamic and integrated phosphoproteomic resource of TCR signaling in primary T cells reveals ITSN2 as a regulator of effector functions Locard-Paulet M. et al., Mol Syst Biol., 2020, 16(7):e9524, PMID: 32618424 The activation trajectory of plasmacytoid dendritic cells in vivo during a viral infectionAbbas A et al., Nat Immunol., 2020, PMID: 32690951 Reticular Fibroblasts Expressing the Transcription Factor WT1 Define a Stromal Niche That Maintains and Replenishes Splenic Red Pulp MacrophagesBellomo A. et al., Immunity, 2020, PMID: 32562599 Immuno-Oncology beyond TILs: Unleashing TILCsDemaria O. et al., Cancer Cell, 2020, 37(4):428-430, PMID: 32289267 Differentiation Paths of Peyer s Patch LysoDCs Are Linked to Sampling Site Positioning, Migration, and T Cell PrimingWagner C. et al., Cell Report, 2020, 31(1):107479., PMID: 32268097 Regulation of coenzyme A levels by degradation: the Ins and Outs Naquet P. et al., Prog Lipid Res., 2020, 29:101028., PMID: 32234503 SnapShot: Natural Killer CellsCrinier A. et al., Cell, 2020, 180: 6, P1280-1280.e1 Establishment and Maintenance of the Macrophage NicheGuilliams M. et al., Immunity, 2020, 52(3):434-451, PMID: 32187515 Bernard Malissen – 2018 – Basilic ProjetMichael Sieweke – 2016 – Macrophage Aging and RejuvenationEric Vivier – 2016 – Targeting  Innate Lymphoid CellsBernard Malissen – 2012 – Integrative biology of T cells and dendritic cells in vivoEric Vivier – 2010 – The Immune Function of Natural KillerERC "Consolidator Grants"Sophie Ugolini – 2014 – Neural regulation of immunityMarc Bajénoff – 2014 – Immunobiology of lymphoid stromal cellsERC "Starting Grants"Réjane Rua - 2020 - Spatiotemporal control of neuroinfection by meningeal macrophagesMarc Dalod – 2011 – Harnessing systems immunology to unravel dendritic cell subset biologyToby Lawrence - 2010 – Targeting tumor associated macrophages in CancerERC "Proof of Concept (PoC) Grant"Eric Vivier - 2019 - MInfla-Tilc

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