Mass Spectrometry of Modified RNA and Proteins |Limbach Group at UC

Time 2021-11-04 10:10:28

Web Name: Mass Spectrometry of Modified RNA and Proteins |Limbach Group at UC

WebSite: http://bearcatms.uc.edu

ID:221496

Keywords:

Modified,RNA,of,Mass,Spectrometry,and,at,UC,modifiedRNA,modifiedtRNA,massspectro

Description:

keywords:modified RNA, modified tRNA, mass spectrometry, ribosome, ribonucleoprotein complexes, post-transcriptional modifications, analytical chemistry, biochemistry, nucleic acid structure, modified nucleosides, transfer RNA, ribonucleic acid, therapeutic oligonucleotides, nucleic acid biomarkers
description:The Limbach Group seeks to develop mass spectrometric methods to characterize post-transcriptionally modified ribonucleic acids (RNAs) and RNA:Protein complexes
Limbach Group Biological Mass Spectrometry

A Member of the Rieveschl Laboratories for Mass Spectrometry
in the McMicken College of Arts Sciences' Department of Chemistry

Site Navigation[Skip] Home Dr. Limbach Research RNA Modifications - MS RNA Modifications - Biology RNA-Protein Complexes Biological Medical Science Protocol Lab Updates... Publications/Software/Databases/Book Chapters Meet the Group Limbach Group News Limbach Group Alumni Group Photo Album Group Meeting Schedule Contact Us UC Tools Canopy Blackboard OneStop Student Email UCMail UCFileSpace UC Flex/ESS Password Help UC VPN Sidebar[Skip] Media, Protocols Lab Updates...

RAMM Software Update (v2) now available.

Editing and methylation at a single site by functionally interdependent activities now published

Dr. Limbach becomes new VP for Research at UC

RoboOligo Software Download now available

Genetic Engineering Biotechnology News article on Collins research

Recent Publications

Oligonucleotide Analysis by Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry in the Absence of Ion-Pair Reagents P.A. Lobue, M. Jora, B. Addepalli, P.A. Limbach,  Journal of Chromatography A (2019) DOI: 10.1016/j.chroma.2019.02.016. PMID: 30772056.    

Transfer RNA Modification Profiles and Codon Decoding Strategies in Methanocaldococcus jannaschii N. Yu, M. Jora, B. Solivio, P. Thakur, C.G. Acevedo-Rocha, L. Randau, V. de Crécy-Lagard, B. Addepalli, P.A. Limbach,  Journal of Bacteriology (2019) 201 e00690-18. DOI: 10.1128/JB.00690-18 PMID: 30745370.

Differentiating positional isomers of nucleoside modifications by higher-energy collisional dissociation mass spectrometry (HCD MS) M Jora, AP Burns, RL Ross, PA Lobue, R Zhao, CM Palumbo, PA Beal, B Addepalli, PA Limbach,  Journal of the American Society for Mass Spectrometry (2018), DOI: 10.1007/s13361-018-1999-6 PMID: 29949056

RNAModMapper: RNA modification mapping software for analysis of mass spectrometry data, N Yu, C Wetzel, X Cao, PA Limbach, Analytical Chemistry (2017) doi: 10.1021/acs.analchem.7b01780 PMID: 28942636

Editing and methylation at a single site by functionally interdependent activities M. A. T. Rubio, K. W. Gaston, K. M. McKenney, I. M.C. Fleming, Z. Paris, P. A. Limbach  and J. D. Alfonzo Nature (2017) doi:10.1038/nature21396 PMID: 28230119

Upcoming Events

May 31 - June 4, 2020

ASMS Annual Meeting
Houston, TX

Limbach Group - Home

The primary interest of Prof. Pat Limbach and members of his research group is to develop new and improved mass spectrometric methods to characterize modified ribonucleic acids (RNAs) and ribonucleoprotein complexes (RNPs). As such, we have active research programs involved in nucleic acid analysis by mass spectrometry, structural biology and medical applications. Details can be accessed below. 

Sequencing of Modified RNAs by Mass Spectrometry

Biological Studies of Modified RNA Nucleosides

Structural Characterization of RNA:Protein Complexes

Medical Research Impacts of Modified RNAs

Our research in these areas has been or is generously supported by the following funding agencies and companies.

 

If you have any questions, would like to discuss our research program, or are interested in supporting our research or your organization would benefit from the talents and expertise of our group, please contact Professor Limbach via phone (513-556-1871) or email (Pat.Limbach at uc.edu).

The following information about our research program at the University of Cincinnati is available on this site:

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The Limbach Group seeks to develop mass spectrometric methods to characterize post-transcriptionally modified ribonucleic acids (RNAs) and RNA:Protein complexes

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