In the Pipeline | Derek Lowe’s commentary on drug discovery and the pharma industry. An editori

Time 2020-12-30 20:04:28

Web Name: In the Pipeline | Derek Lowe’s commentary on drug discovery and the pharma industry. An editori

WebSite: http://blogs.sciencemag.org

ID:151290

Keywords:

drug,on,discovery,

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In the Pipeline | Derek Lowe’s commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine. Derek Lowe's commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine. All content is Derek’s own, and he does not in any way speak for his employer. Here s another one that we make every so often around stately Lowe Manor. When we had it last week, I just had to roast it in the oven normally I d put it on the rotisserie on the grill outside, but weather conditions did not allow it. Like many such recipes, this one is all Read More Note: I ve finally added a Recipes category, since there are quite a few of them floating around the blog over the years, so if you want to find all the kitchen-synthesis posts in one place, it s now possible! We just finished off a loaf of this not long ago around here; it s a recipe that Read More I ll be taking a holiday break, with intermittent blogging. I hope to put in a recipe or two (as often happens around here this time of year), and I ll certainly pop up if we have some big news. Otherwise, from now until January 2nd I ll be on my end-of-the-year schedule. 2020 has been. . .well Read More OK, time to write about the topic that s been the talk of the coronavirus world the last day or two: the new strain that has been detected in the UK. I ll go ahead and put the bottom line right here, and then go into the details: I m not sounding any alarm bells, but this does Read More I ve had several questions about antibody-dependent enhancement, which has always been a worry as the coronavirus vaccines have been developed. I figured it might be worth a look at just what we know about it, why one might be worried, and why (on the other hand) one might be hopeful. The simple definition of ADE Read More Here s a preprint from a large team at Yale with a close look at a less-studied aspect of coronavirus infection. It s been well established by now that a feature of severe cases is a misfiring immune response (the cytokine storm , etc.), and one reason that fatality rates have been going down for hospitalized cases is Read More I wanted to follow up on something that came up much earlier in the coronavirus pandemic. Back in February, a group at BenevolentAI proposed the kinase inhibitor baricitinib as a possible therapeutic for the coronavirus. They identified this through their company s machine-learning approach to the medical literature and disease mechanisms, an Read More Well, it s definitely been a Vaccine Week around here, but it s understandable. And we ll finish off the week with a look at some types that we haven t seen report yet. The news is. . .mixed. First off is a preliminary report on the inactivated virus vaccine from Sinopharm more specifically, their China National Biot Read More For people looking for an accessible writeup on the coronavirus mutational landscape, I can recommend this Reuters article that came out today. It has a lot of good information in it, and a lot of very well-made graphics to show what s going on. Past blog posts on this subject are here, here, here, here, and Read More We now have a complete writeup of the efficacy data from the Oxford/AZ vaccine effort in The Lancet, and I m glad to see it. There have been a number of questions about this candidate and its effects in the clinic, so the chance to get a closer look is welcome. This is of course the Read More

TAGS:drug on discovery 

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