EMBO Molecular Medicine

Time 2020-11-04 21:04:49

Web Name: EMBO Molecular Medicine

WebSite: http://embomolmed.embopress.org

ID:105084

Keywords:

EMBO,Molecular,Medicine,

Description:

Please check your email for instructions on resetting your password. If you do not receive an email within 10 minutes, your email address may not be registered, and you may need to create a new Wiley Online Library account. Can't sign in? Forgot your username? Enter your email address below and we will send you your username If the address matches an existing account you will receive an email with instructions to retrieve your username Report of a patient with the rare lymphatic anomaly, Kaposiform lymphangiomatosis (KLA). CBL proto‐oncogene mutation was identified and she was successfully treated by targeting the MAP kinase pathway. Report of a patient with the rare lymphatic anomaly, Kaposiform lymphangiomatosis (KLA). CBL proto‐oncogene mutation was identified and she was successfully treated by targeting the MAP kinase pathway. This study introduces a novel strategy to accelerate the revascularization of transplanted islets by the fusion of microvascular fragments (MVF) with pancreatic islet cells. These prevascularized islet organoids may be used to improve the success rate of clinical islet transplantation. Aberrant expression of nuclear matrix‐associated proteins (NMPs) has been shown to associate with tumor growth in various human cancers. This study shows that SATB2, a key NMP, and its coactivator CBP critically contribute to glioblastoma (GBM) growth, suggesting SATB2/CBP is a therapeutic target. K. Õunap and K. Reinson discuss the biochemical and functional characterization of the NDUFC2 pathogenic variants identified in children with Leigh syndrome by R. Taylor and colleagues, in this issue of EMBO Molecular Medicine This study used mobility data obtained from Apple users around the world to explore the effect of lockdown on COVID‐19 related mortality. The results suggest that countries that enforced a strict lockdown could have obtained similar mortality figures with less stringent mobility restrictions. F. Mauri and C. Blanpain discuss the identification of a selective vulnerability of Merkel cell carcinomas for LSD1, which could be used for establishing new therapeutic strategies, as reported by A. Obenauf and colleagues in this issue of EMBO Mol. Med. This study identifies GRK2 as a regulator of human skeletogenesis. Loss of GRK2 deregulates the function of two major morphogens in the bone ‐ Hedgehog and canonical Wnt signaling, and manifests in autosomal recessive skeletal ciliopathy syndrome, asphyxiating thoracic dystrophy or Jeune syndrome. Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers. The current article comprehensively reviews recent advances in the molecular characterization of sarcoma subtypes, and describes novel therapeutic targets and biomarkers in this field. This study reveals a major protective role of the IL‐33/ILC2 axis in islet transplantation that could be potentiated as a therapeutic strategy. Adoptive transfer of exvivo expanded IL‐10‐producing ILC2s (ILC210) significantly prolonged allograft survival. This review discusses recent advances in novel therapeutic approaches against cardiac fibrosis in heart failure with preserved ejection fraction and their underlying molecular mechanisms. The GS inhibitor glufosinate is shown to significantly reduce metachronous and synchronous metastasis with no detectable toxicity. This occurs by selective rewiring of both TAMs and MAMs to an antitumoral function, reducing immunosuppression and angiogenesis with a consequent decrease of metastasis. This study provides genetic and biochemical evidence that the intestinal health promoting effects of zinc supplementation is based on a specific, direct effect on members of the microbial community in the ileum. Variants of the transcription factor ALX1 are implicated in the development of Frontonasal Dysplasia. This study explores the role of ALX1 in neural crest cell development and migration in patient‐derived induced pluripotent stem cells and zebrafish. A bioinformatics pipeline was developed for detection of single nucleotide variants and small insertions/deletions from RNA sequencing (RNA‐seq) data. The mutational landscape of 3,217 primary breast cancer transcriptomes in relation to patient survival was made available through a public web portal. Mutations in the POLG gene cause mitochondrial disease with devastating phenotypes in patients. Neural stem cells generated from patient iPSCs showed mitochondrial dysfunction and mtDNA depletion, leading to loss of complex I with concomitant ROS overproduction and disturbed NAD+ metabolism. Report of a patient with the rare lymphatic anomaly, Kaposiform lymphangiomatosis (KLA). CBL proto‐oncogene mutation was identified and she was successfully treated by targeting the MAP kinase pathway. A mouse model of Hutchinson‐Gilford progeria syndrome (HGPS) exhibited reduced ATP availability and elevated oxidative stress, two hallmarks of aging. Treatment with dietary magnesium improved the longevity of HGPS mice. The COVID‐19 pandemic has spread to many countries around the world, but the infection and death rates vary widely. One country that appeared to have kept the infection under control despite limited societal restrictions is Japan. This commentary explores why Japan may have, up to now, been spared an escalation of the SARS‐CoV‐2 infections. Is there more to BCG vaccination and reduced COVID‐19 case fatality rates than a mere correlation? Masayuki Miyasaka comments on this timely but intriguing question and provide some interesting points to consider. This study presents a novel therapy for treatment of obesity‐related diseases. Oral delivery of the mitochondrial protonophore BAM15 markedly reduced weight gain and fat accrual while improving glycemic control. This article reviews the broad topic of cellular senescence, how to manipulate it ‐ novel probes and nanocarriers have potential diagnostic and therapeutic values ‐ and details a number of senotherapies that entered clinical trials. This study describes the discovery and characterization of a novel TREM2 antibody, which induces protective microglial functions and provides a basis for the development of human antibodies with a similar mechanistic profile for treatment of Alzheimer's disease. It is unknown how genetic risk of Alzheimer's disease (AD) manifests itself at the molecular and the cellular level in the brain. Analysis of a TAUtg and an APPtg mouse models show that genetic risk of AD is mainly reflected in the transcriptional responses of microglia to amyloid‐β pathology. What are the prospects for the SARS‐CoV‐2 pandemic in Africa? Virginia Quaresima, Matteo Naldini and Daniela Cirillo analyse the situation in this timely commentary. Neuropathic pain is characterized by hypersensitivity to temperature and touch as well as spontaneous outburst of pain. This study identifies a peptide that can inhibit PICK1 and thereby interfere with insertion of excess glutamate receptor underlying the hypersensitivity in neuropathic pain. Read MoreAbout the coverClose modalView large imageVolume 12,Issue 10,07 October 2020This month's cover highlights the article ALX1‐related Frontonasal Dysplasia Results from Defective Neural Crest Cell Development and Migration by Jonathan Pini, Janina Kueper, Eric C. Liao and colleagues. Utilizing sox10 promoter driving photoconvertible kaede protein in developing zebrafish embryos, the cranial neural crest cells (green) destined for the frontonasal domain of the midface can be labeled (in red), demonstrating ectopic localization when alx1 is disrupted. (Scientific image by David Hu and Eric C. Liao, Massachusetts General Hospital, Shriners Hospital Boston, Harvard Medical School) Olesia Ignatenko, Joni Nikkanen, Alexander Kononov, Nicola Zamboni, Gulayse Ince-Dunn, Anu Suomalainen Sub‐physiological temperatures mimicking surgery‐associated deep hypothermia reset the circadian clock in human cells by nuclear sequestration and warming‐induced re‐release of REV‐ERBα transcripts. Alveolar macrophages produce interferons and activate interferon stimulated genes when challenged with influenza A virus or Sendai virus, but not when challenged with SARS‐CoV‐2, suggesting that its genomic RNA is undetectable for innate immune sensors. Proteomic profiling of matched tumor and normal samples, associates distinct proteomic patterns with patient prognosis in breast cancer. Functional studies invivo support the effectiveness of PYCR1 suppression in combination with chemotherapeutics in clinical settings. Report of a patient with the rare lymphatic anomaly, Kaposiform lymphangiomatosis (KLA). CBL proto‐oncogene mutation was identified and she was successfully treated by targeting the MAP kinase pathway. Astrocyte-specific mtDNA depletion causes spongiotic encephalopathy, aggravated by ketogenic diet or rapamycin. Astrocytes, but not neurons, drive mitochondrial integrated stress response in the CNS.

TAGS:EMBO Molecular Medicine 

<<< Thank you for your visit >>>

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Hot Websites