American Journal of Physiology-Heart and Circulatory Physiology

Time 2020-10-16 13:09:45

Web Name: American Journal of Physiology-Heart and Circulatory Physiology

WebSite: http://ajpheart.physiology.org

ID:84077

Keywords:

of,Journal,American,

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RESEARCH ARTICLESCardiovascular Neurohormonal RegulationFunctional coculture of sympathetic neurons and cardiomyocytes derived from human-induced pluripotent stem cellsAnnika Winbo,Suganeya Ramanan,Emily Eugster,Stefan Jovinge,Jonathan R. Skinner,Johanna M. Montgomery2020 Oct 15: H927-H937https://doi.org/10.1152/ajpheart.00546.2020We present data on a functional coculture between human-induced pluripotent stem cell-derived sympathetic neurons and cardiomyocytes. Moreover, this study adds significantly to the available data on the electrophysiological function of human-induced pluripotent stem cell-derived sympathetic neurons.Integrative Cardiovascular Physiology and PathophysiologyPrediction of hemodynamics after atrial septal defect closure using a framework of circulatory equilibrium in dogsKiyoshi Uike,Keita Saku,Takuya Nishikawa,Kenichiro Yamamura,Hazumu Nagata,Mamoru Muraoka,Shouichi Ohga,Hiroyuki Tsutsui,Kenji Sunagawa2020 Oct 15: H938-H947https://doi.org/10.1152/ajpheart.00098.2020We developed a framework to predict the impact of atrial septal defect (ASD) closure on hemodynamics by incorporating ASD shunt flow into the framework of circulatory equilibrium. The proposed framework accurately predicted hemodynamics after ASD closure. Patient-specific prediction of hemodynamics may be useful for safety management of ASD closure.Integrative Cardiovascular Physiology and PathophysiologyValidation of diagnostic criteria and histopathological characterization of cardiac rupture in the mouse model of nonreperfused myocardial infarctionAnis Hanna, Arti V. Shinde, and Nikolaos G. Frangogiannis2020 Oct 15: H948-H964https://doi.org/10.1152/ajpheart.00318.2020We show that cardiac rupture accounts for 50% of deaths in C57BL/6J mice undergoing nonreperfused myocardial infarction protocols. Overestimation of rupture events in published studies likely reflects the low specificity of hemothorax as a criterion for documentation of rupture. In contrast, identification of a gross rupture site has high specificity and low sensitivity. We also show that mice dying of rupture have increased macrophage influx and attenuated myofibroblast infiltration in the infarct. These findings are consistent with a role for perturbations in the balance between inflammatory and reparative responses in the pathogenesis of postinfarction cardiac rupture. We also report that the male predilection for rupture in infarcted mice is not associated with increased inflammatory activation of myeloid cells.Integrative Cardiovascular Physiology and PathophysiologyExercise heat acclimation has minimal effects on left ventricular volumes, function and systemic hemodynamics in euhydrated and dehydrated trained humansGavin Travers,José González-Alonso,Nathan Riding,David Nichols,Anthony Shaw,Julien D. Périard2020 Oct 15: H965-H979https://doi.org/10.1152/ajpheart.00466.2020This study demonstrates that 10 days of exercise heat acclimation has minimal effects on left ventricular volumes, intrinsic cardiac function, and systemic hemodynamics during prolonged, repeated semirecumbent exercise in moderate heat, where heart rate and blood volume are similar to preacclimation levels. However, progressive dehydration is consistently associated with similar degrees of hyperthermia and tachycardia and reductions in blood volume, diastolic filling of the left ventricle, stroke volume, and cardiac output, regardless of acclimation state. Take a tour of the October 2020 issue of AJP-Heart and Circulatory Physiology in this episode of "From the Editor s Desk" hosted by Editor-in-Chief Dr. Irv Zucker. Enjoy! Endothelial ERBB4 and Cardiac Remodeling - Does neuregulin-1 autocrine signaling by endothelial cells regulate left ventricular remodeling? Listen as Deputy Editor Merry Lindsey (University of Nebraska Medical Center) interviews lead authors Gilles De Keulenaer and Vincent Segers (both at University of Antwerp), along with expert Ganesh Halade (University of South Florida), about the novel work by Dugaucquier et al. [More] Read the article: 10.1152/ajpheart.00176.2020 Behind the Bench Episode 6 with Aurore Lyon - Everyone has a story, and no one is ordinary. That’s our theme for this episode of Behind the Bench from AJP-Heart and Circ. Hosts Lisandra de Castro Bras (East Carolina University) and Jonathan Kirk (Loyola University Chicago) talk with Aurore Lyon (Maastricht University), the first author of “Differentiating the effects of beta-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model,” published in August 2020.[More] Read the article: 10.1152/ajpheart.00275.2020 Vascular Response to Prolonged Sitting in Hypercapnia - What are the potential detrimental interactions between prolonged sitting and mild hypercapnia on autonomic system activity, vascular function, and microvascular oxygenation? In this episode, Editor-in-Chief Irv Zucker (University of Nebraska Medical Center) interviews lead author Song-Young Park (University of Nebraska at Omaha) and expert Camilla Wenceslau (University of Toledo) about the latest study by Headid et al., which found that prolonged sitting attenuated systemic and peripheral vascular endothelial function, as well as microvascular function in healthy adults. [More]Read the article: 10.1152/ajpheart.00354.2020 [U-13C]-glucose and In Vivo Heart Metabolism - What is the “metabolic fate” of glucose in mice with pressure-overload or volume-overload induced cardiac hypertrophy? Listen as Associate Editor Fabio Recchia (Temple University and Scuola Superiore Sant'Anna) interviews lead author, and fellow Associate Editor, Ajay Shah (King’s College London) along with experts Christoph Maack and Edoardo Bertero (both at University Clinic Würzburg) about the new study by Schnelle et al. “Metabolism is integrally linked to structural and functional changes that occur in the remodeling heart.” [More] Read the article here: 10.1152/ajpheart.00219.2020 Assessment of Diastolic Function - Listen as Deputy Editor Merry Lindsey (University of Nebraska Medical Center) interviews authors Leslie Ogilvie and Jeremy Simpson (University of Guelph) and expert Michael Czubryt (University of Manitoba) about the recent Review by Ogilvie et al. on the importance of evaluating best practices in the hemodynamic assessment of diastolic function for animal models. [More]Read the article: 10.1152/ ajpheart.00705.2019 Race, Blood Pressure, and Microvascular Function - Does pre-hypertension, or Stage 1 hypertension, have adverse effects on the microvasculature and the ability of blood vessels to vasodilate? In this episode, Associate Editor Nisha Charkoudian (U.S. Army Research Institute of Environmental Medicine) interviews lead author Brett Wong (Georgia State University) and expert Anna Stanhewicz (University of Iowa) about the new study by Wong and co-authors, in which a local heating protocol on the skin was used to investigate whether race and/or blood pressure affect sensory nerve function. [More]Read the article: 10.1152/ajpheart.00177.2020 Behind the Bench Episode 5 In this episode we take a look behind Behind the Bench, and turn the tables to interview the interviewers. Editor-in-Chief Dr. Irv Zucker (University of Nebraska Medical Center) talks with Dr. Lisandra de Castro Bras (East Carolina University) and Dr. Jonathan Kirk (Loyola University Chicago), our Behind the Bench podcast hosts.

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The American Journal of Physiology-Heart and Circulatory Physiology publishes original investigations on the physiology of the heart, blood vessels, and lymphatics, including experimental and theoretical studies of cardiovascular function at all levels of organization ranging from the intact animal to the cellular, subcellular, and molecular levels.

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