Home Page: Journal of Investigative Dermatology

Time 2020-11-05 04:03:29

Web Name: Home Page: Journal of Investigative Dermatology

WebSite: http://www.jidonline.org

ID:105361

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The JID Connector offers online-only articles of direct clinical relevance for the dermatology and skin biology communities. ORIGINAL ARTICLEClinical impact of antibodies against ustekinumab in psoriasis: an observational, cross-sectional, multicenter study FREE Loeff et al. demonstrate that anti-drug antibodies detected in psoriasis patients treated with the anti-IL-12 and -IL-23 biologic ustekinumab were primarily neutralizing and that presence of these antibodies was associated with lower drug levels and poor clinical responses, supporting the use of drug and anti-drug antibody levels in guiding clinical decisions for these patients.Mohamad et al. report novel nonsense variants in SERPINA12 in two cases of recessive diffuse palmoplantar keratoderma, implicating a loss of vaspin inhibitory activity, increased downstream kallikrein activity, and resultant epidermal thickening and hyperkeratosis in these skin dermatoses. To learn more about the techniques used in this paper, visit the Research Techniques Made Simple article.ORIGINAL ARTICLETargeting PHGDH upregulation reduces glutathione levels and re-sensitizes resistant NRAS mutant melanoma to MEK inhibition FREE Nguyen et al. present evidence that targeting PHGDH, which is upregulated in MEK inhibitor-resistant melanomas, decreases oxidative stress tolerance and cell proliferation in these tumors, suggesting that a combinatory treatment approach may be efficacious to overcome metabolic adaptation and resistance to MEK inhibitors in NRAS-mutant melanomas. Loss of ACK1 Upregulates EGFR and Mediates Resistance to BRAF inhibitionZhenyu Ji, Ching-Ni Njauw, Samantha Guhan, Raj Kumar, Bobby Reddy, Anpuchelvi Rajadurai, Keith Flaherty, Hensin TsaoDOI: https://doi.org/10.1016/j.jid.2020.06.041Publication stage: In Press Journal Pre-ProofJournal of Investigative DermatologyPublished online: November 4, 2020The whey acidic protein WFDC12 is specifically expressed in terminally differentiated keratinocytes and regulates epidermal serine-protease activityPolina Kalinina, Vera Vorstandlechner, Maria Buchberger, Leopold Eckhart, Barbara Lengauer, Bahar Golabi, Maria Laggner, Manuela Hiess, Barbara Sterniczky, Dagmar Födinger, Evgeniya Petrova, Adelheid Elbe-Bürger, Lucian Beer, Alain Hovnanian, Erwin Tschachler, Michael MildnerDOI: https://doi.org/10.1016/j.jid.2020.09.025Publication stage: In Press Journal Pre-ProofJournal of Investigative DermatologyPublished online: November 3, 2020ELL facilitates RNA Polymerase II mediated transcription of human epidermal proliferation genesJingting Li, Varun Bansal, Manisha Tiwari, Yifang Chen, George L. SenDOI: https://doi.org/10.1016/j.jid.2020.09.024Publication stage: In Press Journal Pre-ProofJournal of Investigative DermatologyPublished online: November 2, 2020Regulatory T-cells but not IL-10 impair cell-mediated immunity in HPV+ hyperplastic epitheliumAbate Assefa Bashaw, Chenhao Zhou, Meihua Yu, Lynn Tolley, Graham R. Leggatt, Ian H. Frazer, Janin ChandraDOI: https://doi.org/10.1016/j.jid.2020.10.011Publication stage: In Press Journal Pre-ProofJournal of Investigative DermatologyPublished online: October 28, 2020Automated Quantitative Analysis of Wound Histology using Deep Learning Neural NetworksJake D. Jones, Kyle P. QuinnDOI: https://doi.org/10.1016/j.jid.2020.10.010Publication stage: In Press Journal Pre-ProofJournal of Investigative DermatologyPublished online: October 26, 2020 Access this journal on ScienceDirect Visit ScienceDirect to see if you have access via your institution. Call for Submissions on Autoimmunity JID invites submission of original articles for a Special Issue on Autoimmunity. Areas of interest include autoimmune disease, T-cell and B-cell biology in the context of autoimmune disease, antigen presentation, novel in vitro, or in vivo animal models, tolerance, innate immune response in autoimmune responses, including autoinflammatory response/diseases, mechanisms of sex-bias, and therapeutics in relation to autoimmunity. Submission deadline: April 1, 2021. Contact the Editor at JIDEditor@sidnet.org for submission details. Use the subject heading “Autoimmunity Issue.” For additional details, please see the full announcement.

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